The Immunohistopathology Core C will provide coordinated and efficient facilities to allow reproducible and predictable histochemical processing of tissue samples that will be subsequently analyzed by automated or semiautomated image analysis techniques. The co-principal investigators will supervise a team that has an established record in quantitative tissue morphometrics, cell counting, immunohistopathology, in situ hybridization, gel analysis, and autoradiography. Accuracy and reproducible outcomes are likely to result from the approach. The co-principal investigators and staff will provide oversight for the facility including scheduling, training of project personnel, and supervising use of the image analysis facilities. The enhanced analysis system that will be used in this proposal is unique in that it replaces a variety of less sensitive, cumbersome technologies that have previously been used for this purpose. Technical personnel in the facility will all be well versed in the employment of the hardware and software in the proposed imaging center, as it applies to immunopathology, densitometry, and fluorescent techniques. The additional technician requested will provide support to Projects 2-4.
| Heffner, Kathi L; Kiecolt-Glaser, Janice K; Glaser, Ronald et al. (2014) Stress and anxiety effects on positive skin test responses in young adults with allergic rhinitis. Ann Allergy Asthma Immunol 113:13-8 |
| Gouin, Jean-Philippe; Carter, C Sue; Pournajafi-Nazarloo, Hossein et al. (2012) Plasma vasopressin and interpersonal functioning. Biol Psychol 91:270-4 |
| Gouin, Jean-Philippe; Kiecolt-Glaser, Janice K (2012) The impact of psychological stress on wound healing: methods and mechanisms. Crit Care Nurs Clin North Am 24:201-13 |
| Gouin, Jean-Philippe; Carter, C Sue; Pournajafi-Nazarloo, Hossein et al. (2010) Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology 35:1082-90 |
| Edwards, Kate M; Bosch, Jos A; Engeland, Christopher G et al. (2010) Elevated macrophage migration inhibitory factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol. Brain Behav Immun 24:1202-8 |
| Graham, Jennifer E; Glaser, Ronald; Loving, Timothy J et al. (2009) Cognitive word use during marital conflict and increases in proinflammatory cytokines. Health Psychol 28:621-30 |
| Kiecolt-Glaser, Janice K; Heffner, Kathi L; Glaser, Ronald et al. (2009) How stress and anxiety can alter immediate and late phase skin test responses in allergic rhinitis. Psychoneuroendocrinology 34:670-80 |
| Ariza, Maria-Eugenia; Glaser, Ronald; Kaumaya, Pravin T P et al. (2009) The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway. J Immunol 182:851-9 |
| Engeland, Christopher G; Sabzehei, Bahareh; Marucha, Phillip T (2009) Sex hormones and mucosal wound healing. Brain Behav Immun 23:629-35 |
| Kostyk, S K; Popovich, P G; Stokes, B T et al. (2008) Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse. Neuroscience 156:498-514 |
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