Abstract

This application is proposed in response to the announcement from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) through the Division of Kidney, Urologic and Hematologic Diseases (DKUHD) to establish a limited number of kidney and urological research centers. Northwestern University proposes to establish such a Center with its central theme on the study of cellular and chemical aspects of benign prostatic growth.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK039250-04
Application #
3105848
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1987-09-01
Project End
1992-07-31
Budget Start
1990-08-01
Budget End
1991-07-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Kassen, A E; Sensibar, J A; Sintich, S M et al. (2000) Autocrine effect of DHT on FGF signaling and cell proliferation in LNCaP cells: role of heparin/heparan-degrading enzymes. Prostate 44:124-32
Ilio, K Y; Nemeth, J A; Sensibar, J A et al. (2000) Prostatic ductal system in rats: changes in regional distribution of extracellular matrix proteins during castration-induced regression. Prostate 43:10-Mar
Lee, C; Sintich, S M; Mathews, E P et al. (1999) Transforming growth factor-beta in benign and malignant prostate. Prostate 39:285-90
Sensibar, J A; Pruden, S J; Kasjanski, R Z et al. (1999) Differential growth rates in stromal cultures of human prostate derived from patients of varying ages. Prostate 38:110-7
Kim, I Y; Ahn, H J; Lang, S et al. (1998) Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients. Clin Cancer Res 4:1625-30
Kim, I Y; Zelner, D J; Lee, C (1998) The conventional transforming growth factor-beta (TGF-beta) receptor type I is not required for TGF-beta 1 signaling in a human prostate cancer cell line, LNCaP. Exp Cell Res 241:151-60
Grayhack, J T; Kozlowski, J M; Lee, C (1998) The pathogenesis of benign prostatic hyperplasia: a proposed hypothesis and critical evaluation. J Urol 160:2375-80
Sherwood, E R; Van Dongen, J L; Wood, C G et al. (1998) Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells. Br J Cancer 77:855-61
Grayhack, J T; Sensibar, J A; Ilio, K Y et al. (1998) Synergistic action of steroids and spermatocele fluid on in vitro proliferation of prostate stroma. J Urol 159:2202-9
Gann, P H; Chatterton, R; Vogelsong, K et al. (1997) Epidermal growth factor-related peptides in human prostatic fluid: sources of variability in assay results. Prostate 32:234-40

Showing the most recent 10 out of 59 publications