Abstract

The Facility for Element Analysis of Microdroplets provides investigators within the Renal Center with the capability of analyzing the element composition of extremely small biological fluid samples. Specimen which can be analyzed in this way include the perfusate obtained from isolated perfused tubular segments and droplets obtained by micropuncture. In most cases, the size of the fluid samples precludes the analysis by any other known method. The availability of this facility as a Center Core will guarantee a short turnover time and provide the investigators with an immediate feedback of the experimental results. Furthermore, potential problems associated with the shipping of fluid samples are avoided.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK039258-03
Application #
3897619
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Chambrey, R; Achard, J M; St John, P L et al. (1997) Evidence for an amiloride-insensitive Na+/H+ exchanger in rat renal cortical tubules. Am J Physiol 273:C1064-74
Wang, D; Balkovetz, D F; Warnock, D G (1995) Mutational analysis of transmembrane histidines in the amiloride-sensitive Na+/H+ exchanger. Am J Physiol 269:C392-402
Brown, S A; Finco, D R; Navar, L G (1995) Impaired renal autoregulatory ability in dogs with reduced renal mass. J Am Soc Nephrol 5:1768-74
Lewis, J L; Warnock, D G (1994) Renal apical membrane sodium-hydrogen exchange in genetic salt-sensitive hypertension. Hypertension 24:491-8
Botero-Velez, M; Curtis, J J; Warnock, D G (1994) Brief report: Liddle's syndrome revisited--a disorder of sodium reabsorption in the distal tubule. N Engl J Med 330:178-81
Kudo, L H; Hawk, C T; Schafer, J A (1994) Sodium and water transport in cortical collecting duct of Dahl salt-resistant rat. Am J Physiol 267:F583-91
Allon, M; Parris, M (1993) Calcitriol stimulates Na(+)-Pi cotransport in a subclone of opossum kidney cells (OK-7A) by a genomic mechanism. Am J Physiol 264:F404-10
Wuthrich, R P; Jenkins, T A; Snyder, T L (1993) Regulation of cytokine-stimulated vascular cell adhesion molecule-1 expression in renal tubular epithelial cells. Transplantation 55:172-7
Chen, P Y; St John, P L; Kirk, K A et al. (1993) Hypertensive nephrosclerosis in the Dahl/Rapp rat. Initial sites of injury and effect of dietary L-arginine supplementation. Lab Invest 68:174-84
Wuthrich, R P; Sekar, P (1993) Effect of dexamethasone, 6-mercaptopurine and cyclosporine A on intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression. Biochem Pharmacol 46:1349-53

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