One of the main goals of this """"""""Multi-Institutional Research Center of Excellence in Pediatric Nephrology and Urology"""""""" is to improve the understanding of kidney and urologic diseases in children by promoting fundamental and applied research efforts that will serve as the basis for new preventive, diagnostic and therapeutic strategies. To achieve this long-term goal, initiatives need to be developed in the following area: . New technology has to be made available to scientists as rapidly as possible . Major efforts are needed to attract young and talented scientists and physicians to Pediatric Nephrology and Urology . Special efforts are to be made to attract minority and women to develop an interest in Pediatric Nephrology and Urology . Education and training of health professionals is required to achieve successful management of neonates, infants, children and adolescents with kidney diseases

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Chevalier, Robert L (2004) Perinatal obstructive nephropathy. Semin Perinatol 28:124-31
Kiley, Susan C; Thornhill, Barbara A; Tang, Shiow-Shih et al. (2003) Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. Kidney Int 63:33-42
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Lange-Sperandio, Barbel; Cachat, Francois; Thornhill, Barbara A et al. (2002) Selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice. Kidney Int 61:516-24
Chevalier, R L (2001) The moth and the aspen tree: sodium in early postnatal development. Kidney Int 59:1617-25
Chevalier, R L; Cachat, F (2001) Role of angiotensin II in chronic ureteral obstruction. Contrib Nephrol :250-60
Hilgers, K F; Veelken, R; Muller, D N et al. (2001) Renin uptake by the endothelium mediates vascular angiotensin formation. Hypertension 38:243-8
Malik, R K; Thornhill, B A; Chang, A Y et al. (2001) Renal apoptosis parallels ceramide content after prolonged ureteral obstruction in the neonatal rat. Am J Physiol Renal Physiol 281:F56-61
Li, X X; Xu, J; Zheng, S et al. (2001) D(1) dopamine receptor regulation of NHE3 during development in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 280:R1650-6
Malik, R K; Thornhill, B A; Chang, A Y et al. (2000) Apoptosis parallels ceramide content in the developing rat kidney. Pediatr Nephrol 15:188-91

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