Abstract

This competing renewal of our Pediatric Center Grant will focus on fibrotic sequelae of childhood renal diseases. The first project, with Dr. Fogo as the PI will focus on tubular interstitial fibrosis mechanisms related to angiotensin and plasminogen activator inhibitor-1. The second project with Dr. Ichikawa as PI will focus on the function of the renin angiotensin system in the macrophage and its contribution to interstitial fibrosis. The third project, headed by Dr. Kon, will focus on the role of the renin angiotensin system in the macrophage in atherosclerosis. The fourth project headed by a new member of the center grant, Dr. Allison Eddy at the Children's and Regional Medical Center, Seattle, will focus on macrophage scavenger receptors and their processing of low density lipoproteins and impact on renal fibrosis. Three pilot projects include a clinical pilot study (Dr. Jabs, PI) to establish measures of carotid artery intima media thickness in children with chronic kidney disease as a marker of cardiovascular disease risk; a basic science study (Dr. Upadhya, PI) investigating pathogenesis of fibrosis in a model of polycystic kidney disease and lastly a pilot study (Dr. Matsusaka, PI) to determine mechanisms of podocyte injury in novel transgenic animal models with HIV infection. These projects will be supported by an animal genotyping and phenotyping core and administrative core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK044757-13
Application #
6721228
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J1))
Program Officer
Moxey-Mims, Marva M
Project Start
1992-04-01
Project End
2007-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
13
Fiscal Year
2004
Total Cost
$1,038,668
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Kaseda, Ryohei; Jabs, Kathy; Hunley, Tracy E et al. (2015) Dysfunctional high-density lipoproteins in children with chronic kidney disease. Metabolism 64:263-73
Yamamoto, Suguru; Zhong, Jiayong; Yancey, Patricia G et al. (2015) Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype. Atherosclerosis 242:56-64
Zhong, Jianyong; Yang, Hai-Chun; Kon, Valentina et al. (2014) Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts. Lab Invest 94:633-44
Yamamoto, Suguru; Kon, Valentina (2014) Chronic kidney disease induced dysfunction of high density lipoprotein. Clin Exp Nephrol 18:251-4
Yang, Hai-Chun; Fogo, Agnes B (2014) Mechanisms of disease reversal in focal and segmental glomerulosclerosis. Adv Chronic Kidney Dis 21:442-7
Zuo, Yiqin; Chun, Bongkwon; Potthoff, Sebastian A et al. (2013) Thymosin ?4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int 84:1166-75
Miyazawa, Tomoki; Zeng, Fenghua; Wang, Suwan et al. (2013) Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression. Kidney Int 84:1176-88
Zhong, Jianyong; Perrien, Daniel Scott; Yang, Hai-Chun et al. (2012) Maturational regression of glomeruli determines the nephron population in normal mice. Pediatr Res 72:241-8
Howard, Christiana; Tao, Shixin; Yang, Hai-Chun et al. (2012) Specific deletion of glycogen synthase kinase-3? in the renal proximal tubule protects against acute nephrotoxic injury in mice. Kidney Int 82:1000-9
Eddy, Allison A; López-Guisa, Jesús M; Okamura, Daryl M et al. (2012) Investigating mechanisms of chronic kidney disease in mouse models. Pediatr Nephrol 27:1233-47

Showing the most recent 10 out of 131 publications