Abstract

Core A breeds, screens, maintains and supplies hypercalciuric rats to Projects 1, 2 and 4, urine for protein evaluation to Projects 3 and 4, and bone cells to Project 1. Each rat is screened for hypercalciuria prior to being utilized in protocols. Rats are placed on matched high and low calcium diets as needed for each protocol and appropriate urine collections are performed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK047631-04
Application #
5210802
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Lieske, J C; Toback, F G; Deganello, S (2001) Sialic acid-containing glycoproteins on renal cells determine nucleation of calcium oxalate dihydrate crystals. Kidney Int 60:1784-91
Bushinsky, D A; Grynpas, M D; Asplin, J R (2001) Effect of acidosis on urine supersaturation and stone formation in genetic hypercalciuric stone-forming rats. Kidney Int 59:1415-23
Bushinsky, D A; Parker, W R; Asplin, J R (2000) Calcium phosphate supersaturation regulates stone formation in genetic hypercalciuric stone-forming rats. Kidney Int 57:550-60
Lieske, J C; Toback, F G (2000) Renal cell-urinary crystal interactions. Curr Opin Nephrol Hypertens 9:349-55
Koka, R M; Huang, E; Lieske, J C (2000) Adhesion of uric acid crystals to the surface of renal epithelial cells. Am J Physiol Renal Physiol 278:F989-98
Scheinman, S J; Cox, J P; Lloyd, S E et al. (2000) Isolated hypercalciuria with mutation in CLCN5: relevance to idiopathic hypercalciuria. Kidney Int 57:232-9
Lieske, J C; Huang, E; Toback, F G (2000) Regulation of renal epithelial cell affinity for calcium oxalate monohydrate crystals. Am J Physiol Renal Physiol 278:F130-7
Nakagawa, Y; Asplin, J R; Goldfarb, D S et al. (2000) Clinical use of cystine supersaturation measurements. J Urol 164:1481-5
Nakagawa, Y; Coe, F L (1999) A modified cyanide-nitroprusside method for quantifying urinary cystine concentration that corrects for creatinine interference. Clin Chim Acta 289:57-68
Frick, K K; Bushinsky, D A (1999) In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expression. Am J Physiol 277:F750-5

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