Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
2P50DK057301-07
Application #
7070160
Study Section
Special Emphasis Panel (ZDK1-GRB-9 (O1))
Project Start
2005-09-30
Project End
2010-08-31
Budget Start
2005-09-30
Budget End
2006-08-31
Support Year
7
Fiscal Year
2005
Total Cost
$183,750
Indirect Cost
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Parnell, Stephen C; Magenheimer, Brenda S; Maser, Robin L et al. (2018) A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD. Hum Mol Genet 27:3313-3324
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Zhou, Xia; Fan, Lucy X; Li, Keguo et al. (2014) SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet 23:1644-55
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Parnell, Stephen C; Puri, Sanjeev; Wallace, Darren P et al. (2012) Protein phosphatase-1ýý interacts with and dephosphorylates polycystin-1. PLoS One 7:e36798
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Nims, Nancy M; Vassmer, Dianne; Maser, Robin L (2011) Effect of PKD1 gene missense mutations on polycystin-1 membrane topogenesis. Biochemistry 50:349-55
Reif, Gail A; Yamaguchi, Tamio; Nivens, Emily et al. (2011) Tolvaptan inhibits ERK-dependent cell proliferation, Clýýý secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin. Am J Physiol Renal Physiol 301:F1005-13

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