Abstract

Benign Prostatic Hyperplasia (BPH)/lower urinary tract symptoms (LUTS) is a disease that significantly affects the quality of life in aging men. Though BPH has been well recognized to present itself as symptomatic or asymptomatic disease, the two forms were thought to be indistinguishable at the molecular level. To elucidate the molecular differences underlying BPH, gene expression profiles from the prostate transition zone were analyzed using microarrays. These results identified several genes that appear to differentiate BPH from individuals with severe symptoms from those with asymptomatic BPH. This application focuses on one of these genes namely, JI^-27. JM-27 (also known as PAGE4/GAGEC1) is remarl

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK082998-03
Application #
8328087
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
2014-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
3
Fiscal Year
2011
Total Cost
$293,191
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Na, Rong; Helfand, Brian T; Chen, Haitao et al. (2017) A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Prostate 77:1213-1220
Kulac, Ibrahim; Gumuskaya, Berrak; Drake, Charles G et al. (2016) Peripheral Zone Inflammation Is Not Strongly Associated With Lower Urinary Tract Symptom Incidence and Progression in the Placebo Arm of the Prostate Cancer Prevention Trial?. Prostate 76:1399-408
Torkko, Kathleen C; Wilson, R Storey; Smith, Elizabeth E et al. (2015) Prostate Biopsy Markers of Inflammation are Associated with Risk of Clinical Progression of Benign Prostatic Hyperplasia: Findings from the MTOPS Study. J Urol 194:454-61
Mondul, Alison M; Giovannucci, Edward; Platz, Elizabeth A (2014) A prospective study of obesity, and the incidence and progression of lower urinary tract symptoms. J Urol 191:715-21
Mondul, Alison M; Giovannucci, Edward; Platz, Elizabeth A (2013) A prospective study of statin drug use and lower urinary tract symptoms in older men. Am J Epidemiol 178:797-803
Platz, Elizabeth A; Joshu, Corinne E; Mondul, Alison M et al. (2012) Incidence and progression of lower urinary tract symptoms in a large prospective cohort of United States men. J Urol 188:496-501
Mooney, Steven M; Rajagopalan, Krithika; Williams, Brenten H et al. (2011) Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses. J Cell Biochem 112:1066-75
Rajagopalan, Krithika; Mooney, Steven M; Parekh, Nehal et al. (2011) A majority of the cancer/testis antigens are intrinsically disordered proteins. J Cell Biochem 112:3256-67
Zeng, Yu; He, Yanan; Yang, Fan et al. (2011) The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein. J Biol Chem 286:13985-94