The theme of the Pacific Northwest Center for Human Health and Ocean Sciences is elucidation of the mechanisms that govern relationships between marine processes and public health consequences of harmful algal blooms. Consistent with RFA ES-03-003, the investigators have designed a multidisciplinary research team including faculty from several academic institutions and departments in partnership with state and federal governmental organizations to facilitate both mechanistic and applied research on production and adverse affects of harmful algal blooms. The proposed Center will be a joint collaboration effort between two top-rated academic programs, the University of Washington Schools of Oceanography, Marine Affairs, and Aquatic and Fishery Science within the College of Ocean and Fishery Science and the Department of Environmental and Occupational Health Sciences (DEOHS) in the School of Public Health and Community Medicine. Also participating, both financially and with shared expertise, are investigators from the National Atmospheric Administration (NOAA), Washington State Department of Health, Washington State Department of Ecology, the Institute for Systems Biology, and the University of Maryland. The premise underlying this research is that genetic and environmental variability defines the toxicity and dynamics of harmful algal blooms (HABs), the retention of the toxin by shellfish and the human populations that are susceptible to toxicological impacts. The theme of this Center emphasizes the importance of understanding and characterizing environmental conditions and forces that determine the development of HABs and the factors that determine human susceptibility to risk associated with exposure to these. This is responsive to the directives in the NSF and NIEHS sponsored roundtable on Oceans and Human Health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center (P50)
Project #
1P50ES012762-01
Application #
6734338
Study Section
Special Emphasis Panel (ZES1-LKB-E (OC))
Program Officer
Tyson, Frederick L
Project Start
2004-02-16
Project End
2008-12-31
Budget Start
2004-02-16
Budget End
2004-12-31
Support Year
1
Fiscal Year
2004
Total Cost
$516,000
Indirect Cost
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Port, Jesse A; Cullen, Alison C; Wallace, James C et al. (2014) Metagenomic frameworks for monitoring antibiotic resistance in aquatic environments. Environ Health Perspect 122:222-8
Hubbard, Katherine A; Olson, Claire H; Armbrust, E Virginia (2014) Molecular characterization of Pseudo-nitzschia community structure and species ecology in a hydrographically complex estuarine system (Puget Sound, Washington, USA). Mar Ecol Prog Ser 507:39-55
Armstrong, Jenna L; Fenske, Richard A; Yost, Michael G et al. (2013) Comparison of polyurethane foam and XAD-2 sampling matrices to measure airborne organophosphorus pesticides and their oxygen analogs in an agricultural community. Chemosphere 92:451-7
Port, Jesse A; Parker, Micaela S; Kodner, Robin B et al. (2013) Identification of G protein-coupled receptor signaling pathway proteins in marine diatoms using comparative genomics. BMC Genomics 14:503
Giordano, Gennaro; Kavanagh, Terrance J; Faustman, Elaine M et al. (2013) Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione. Toxicol Sci 132:399-408
Marshall, Katharine T; Morris, Robert M (2013) Isolation of an aerobic sulfur oxidizer from the SUP05/Arctic96BD-19 clade. ISME J 7:452-5
Bender, Sara J; Parker, Micaela S; Armbrust, E Virginia (2012) Coupled effects of light and nitrogen source on the urea cycle and nitrogen metabolism over a diel cycle in the marine diatom Thalassiosira pseudonana. Protist 163:232-51
Port, Jesse A; Wallace, James C; Griffith, William C et al. (2012) Metagenomic profiling of microbial composition and antibiotic resistance determinants in Puget Sound. PLoS One 7:e48000
Tsuchiya, Ami; Duff, Rob; Stern, Alan H et al. (2012) Single blood-Hg samples can result in exposure misclassification: temporal monitoring within the Japanese community (United States). Environ Health 11:37

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