The overall goal of this Facility Core is to: conduct studies aimed at defining the effects of chronic low-level domoic acid (DA) exposure on neurobehavioral development. The Neurobehavioral Assessment Facility Core will provide services for the Mechanisms of Toxicity Research Project and the Human Exposure Research Project. In particular, the Core will provide services for two activities, one involving prenatal exposure to domoic acid, and the other early postnatal exposure. The Core will provide the capability of evaluating the functional development of the central nervous system, through the use of a Developmental Neurotoxicity Test Battery. This test battery includes measures of motor coordination, reflex responses, nociception, learning and memory, and the appearance of developmental landmarks in mice.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center (P50)
Project #
5P50ES012762-03
Application #
7186739
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
3
Fiscal Year
2006
Total Cost
$45,192
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wallace, James C; Youngblood, Jessica E; Port, Jesse A et al. (2018) Variability in metagenomic samples from the Puget Sound: Relationship to temporal and anthropogenic impacts. PLoS One 13:e0192412
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Giordano, Gennaro; Kavanagh, Terrance J; Faustman, Elaine M et al. (2013) Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione. Toxicol Sci 132:399-408
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Bender, Sara J; Parker, Micaela S; Armbrust, E Virginia (2012) Coupled effects of light and nitrogen source on the urea cycle and nitrogen metabolism over a diel cycle in the marine diatom Thalassiosira pseudonana. Protist 163:232-51
Port, Jesse A; Wallace, James C; Griffith, William C et al. (2012) Metagenomic profiling of microbial composition and antibiotic resistance determinants in Puget Sound. PLoS One 7:e48000
Tsuchiya, Ami; Duff, Rob; Stern, Alan H et al. (2012) Single blood-Hg samples can result in exposure misclassification: temporal monitoring within the Japanese community (United States). Environ Health 11:37

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