This is a multi-disciplinary, trauma center application for Study of Wound Healing and Wound Infection. It consists of a core section and five parts: 1. Studies on oxygenation, perfusion, and healing in humans. 2. Tissue flaps and a study of the physiologic dimension of wound infection. 3. The growth environment and diabetes. 4. Wound healing angiogenesis 5. Control of collagen synthesis in wounds The central theme is the coordinated dissection of wound extracellular environment and the effects of its components on infection, collagen synthesis, angiogenesis, and fibroplasia. The goal is to understand why and how injuries heal; what stops them from healing and disposes toward infection; and what can be done to assure useful repair free of infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM027345-09
Application #
3106062
Study Section
(SRC)
Project Start
1980-01-01
Project End
1989-12-31
Budget Start
1988-07-01
Budget End
1989-12-31
Support Year
9
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Ogino, Tetsuya; Than, Tin Aung; Hosako, Mutsumi et al. (2009) Taurine chloramine: a possible oxidant reservoir. Adv Exp Med Biol 643:451-61
Hunt, Thomas K; Aslam, Rummana S; Beckert, Stefan et al. (2007) Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Antioxid Redox Signal 9:1115-24
Hansen, Scott L; Dosanjh, Amarjit; Young, David M et al. (2006) Hemangiomas and homeobox gene expression. J Craniofac Surg 17:767-71
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Fries, Richard B; Wallace, William A; Roy, Sashwati et al. (2005) Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutat Res 579:172-81
Hansen, Scott L; Myers, Connie A; Charboneau, Aubri et al. (2003) HoxD3 accelerates wound healing in diabetic mice. Am J Pathol 163:2421-31
Hansen, Scott L; Young, David M; Boudreau, Nancy J (2003) HoxD3 expression and collagen synthesis in diabetic fibroblasts. Wound Repair Regen 11:474-80
Trabold, Odilo; Wagner, Silvia; Wicke, Corinna et al. (2003) Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen 11:504-9

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