Abstract

Several projects within the Trauma Center will include efforts to examine the expression of specific proteins. Because of low abundance or the absence of enzymatic activity (e.g., the cytokines) the evaluation of many of these proteins will require specific nucleic acid and antibody probes. The Molecular Biology core will allow us to centralize expertise and instruments in a facility designed to assist investigators in the development and use of such probes. Through active participation in research seminars and workshops, the Core will also play an important training role for investigators and their colleagues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM038529-09
Application #
5212119
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Galvagno Jr, Samuel M; Fox, Erin E; Appana, Savitri N et al. (2017) Outcomes after concomitant traumatic brain injury and hemorrhagic shock: A secondary analysis from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios trial. J Trauma Acute Care Surg 83:668-674
Moore, Frederick A; Moore, Ernest E; Billiar, Timothy R et al. (2017) The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure. J Trauma Acute Care Surg 83:520-531
Galvagno Jr, Samuel M; Fox, Erin E; Appana, Savitri N et al. (2017) Outcomes Following Concomitant Traumatic Brain Injury and Hemorrhagic Shock: A Secondary Analysis from the PROPPR Trial. J Trauma Acute Care Surg :
Deng, Xiyun; Cao, Yanna; Huby, Maria P et al. (2016) Adiponectin in Fresh Frozen Plasma Contributes to Restoration of Vascular Barrier Function After Hemorrhagic Shock. Shock 45:50-54
Matijevic, Nena; Wang, Yao-Wei W; Holcomb, John B et al. (2015) Microvesicle phenotypes are associated with transfusion requirements and mortality in subjects with severe injuries. J Extracell Vesicles 4:29338
Kozar, Rosemary A; Pati, Shibani (2015) Syndecan-1 restitution by plasma after hemorrhagic shock. J Trauma Acute Care Surg 78:S83-6
Hobson, Charles; Singhania, Girish; Bihorac, Azra (2015) Acute Kidney Injury in the Surgical Patient. Crit Care Clin 31:705-23
Adams, Sasha D; Cotton, Bryan A; Wade, Charles E et al. (2013) Do not resuscitate status, not age, affects outcomes after injury: an evaluation of 15,227 consecutive trauma patients. J Trauma Acute Care Surg 74:1327-30
Radwan, Zayde A; Bai, Yu; Matijevic, Nena et al. (2013) An emergency department thawed plasma protocol for severely injured patients. JAMA Surg 148:170-5
Dial, Elizabeth J; Tran, Duy M; Hyman, Ari et al. (2013) Endotoxin-induced changes in phospholipid dynamics of the stomach. J Surg Res 180:140-6

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