The Sorger group will continue its quantitative analysis of signal transduction in mammalian cells withparticular focus on pathways downstream of ErbB, IGF1 and cMet growth factor receptors and TNF, TRAILand Fas death receptors. Measurement in single cells and cell populations will be accompanied bymathematical modeling using a variety of methods ranging from purely statistical to physico-chemical. TheGunawardena group will work closely with members of the Sorger group, and with other CDP labs, indeveloping new methods to model and analyze biological networks. Development and application of theLittle b programming environment will be of particular importance.With respect to Core activities the focus will be on efficient reagent acquisition, generation and distribution inthe Molecular Genetics core and web-based information technologies in the Informatics Core. Theinformatics core will develop methods for integrating experiments and models, while also providingprogramming support for central activities resources as CDPWiki, the CDP web site and conferenceregistration.The Outreach core is responsible for overall management of non-scientific programs in CDP across twocampuses, with particular focus on annual meetings, retreats, student and educational activities andrecruiting for the sabbatical program. Financial support and scientific mentors for the New England ScienceSymposium will also be provided. HMS-based administration will support the cores in their programmaticfunctions.The outreach core will work closely with the Scientific Coordination team, which comprises highlyexperienced postdoctoral fellows, as well as with the PI, in preparing annual reports, updating the web siteand guiding collaborative projects among CDP labs.
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