New project 6: The costs and benefits of environmental sensing in budding yeast (Ramanathan) (#33) We have used single-cell experiments, modeling and theory to investigate the costs and benefits of a starvation response (sporulation) in budding yeast. We investigated the variability between individuals in the kinetics of decision-making using sporulation as a model. We found 2.5 fold variability in the timing of sporulation after a population of cells is transferred from rich to starvation medium. By following fluorescent proteins, we divided the period before the second meiotic division into three periods: the time from the start of starvation to induction of the first wave of targets of Ime1, the time from the onset of the first wave to Ml and the time from Ml to Mil. The duration of the three phases is independent of each other demonstrating that they are each subject to intrinsic variability that is the result of differences in the levels of different molecules. This work38 will form the basis for our future experiments, which are designed to investigate the costs and benefits of different strategies for sensing and responding to environmental variables. Sharad Ramanathan became a Bauer Fellow in 2004 and joined CMB in 2006.
| Westerman, Erica L; VanKuren, Nicholas W; Massardo, Darli et al. (2018) Aristaless Controls Butterfly Wing Color Variation Used in Mimicry and Mate Choice. Curr Biol 28:3469-3474.e4 |
| Bonham, Kevin S; Wolfe, Benjamin E; Dutton, Rachel J (2017) Extensive horizontal gene transfer in cheese-associated bacteria. Elife 6: |
| Hormoz, Sahand; Singer, Zakary S; Linton, James M et al. (2016) Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements. Cell Syst 3:419-433.e8 |
| Renn, Suzy C P; O'Rourke, Cynthia F; Aubin-Horth, Nadia et al. (2016) Dissecting the Transcriptional Patterns of Social Dominance across Teleosts. Integr Comp Biol 56:1250-1265 |
| Kastman, Erik K; Kamelamela, Noelani; Norville, Josh W et al. (2016) Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species. MBio 7: |
| Lavrentovich, Maxim O; Wahl, Mary E; Nelson, David R et al. (2016) Spatially Constrained Growth Enhances Conversional Meltdown. Biophys J 110:2800-2808 |
| Battle, Christopher; Broedersz, Chase P; Fakhri, Nikta et al. (2016) Broken detailed balance at mesoscopic scales in active biological systems. Science 352:604-7 |
| Tamari, Zvi; Yona, Avihu H; Pilpel, Yitzhak et al. (2016) Rapid evolutionary adaptation to growth on an 'unfamiliar' carbon source. BMC Genomics 17:674 |
| Kim, Wook; Levy, Stuart B; Foster, Kevin R (2016) Rapid radiation in bacteria leads to a division of labour. Nat Commun 7:10508 |
| Muller, Nicolas; Piel, Matthieu; Calvez, Vincent et al. (2016) A Predictive Model for Yeast Cell Polarization in Pheromone Gradients. PLoS Comput Biol 12:e1004795 |
Showing the most recent 10 out of 205 publications
