A Center for Chemical Methodology and Library Design is proposed. The scientific focus of this Center will be the development of innovative combinatorial chemistry. The focus throughout is on techniques capable of leading to libraries containing molecules that (1) that utilize new principles of scaffold design (and especially the incorporation of multiple scaffold cores into a given library) and (2) are likely to have pharmacological activity based on sound drug design principles. This work will be facilitated through additional projects that focus on novel methods for phase trafficking and purification as well as organometallic chemistry. The proposed center will comprise three cores (administration, synthesis, and library design and analysis) and the following thematic scientific efforts: (1) New Phase-Trafficking Methodologies for Combinatorial Chemistry, (2) Biomimetics, (3) Organometallic Combinatorial Chemistry, and (4) Natural Products and Privileged Structures. Scientists at the University of Kansas, Kansas State University, and Iowa State University will direct the proposed work. It will be facilitated through the establishment of a centralized laboratory for combinatorial chemistry research in the newly acquired Life Sciences Research Laboratory (LSRL) at the University of Kansas in Lawrence, KS. The laboratory facility is adjacent to a high-throughput screening laboratory and other life science researchers in the Higuchi Biosciences Center, which will facilitate biological collaborations.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
3P50GM069663-02S1
Application #
6949788
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Schwab, John M
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$75,000
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Wang, Xuewei; Jolliffe, Aaron; Carr, Benjamin et al. (2018) Nitric oxide-releasing semi-crystalline thermoplastic polymers: preparation, characterization and application to devise anti-inflammatory and bactericidal implants. Biomater Sci 6:3189-3201
Knewtson, Kelsey E; Rane, Digamber; Peterson, Blake R (2018) Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis. ACS Chem Biol 13:2595-2602
Ramakumar, Kinthada; Maji, Tapan; Partridge, James J et al. (2017) Synthesis of Spirooxindoles via the tert-Amino Effect. Org Lett 19:4014-4017
Faisal, Saqib; Zang, Qin; Maity, Pradip K et al. (2017) Development and Application of a Recyclable High-Load Magnetic Co/C Hybrid ROMP-Derived Benzenesulfonyl Chloride Reagent and Utility of Corresponding Analogues. Org Lett 19:2274-2277
Koen, Yakov M; Liu, Ke; Shinogle, Heather et al. (2016) Comparative Toxicity and Metabolism of N-Acyl Homologues of Acetaminophen and Its Isomer 3'-Hydroxyacetanilide. Chem Res Toxicol 29:1857-1864
Gold, Ben; Smith, Robert; Nguyen, Quyen et al. (2016) Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis. J Med Chem 59:6027-44
Faisal, Saqib; Maity, Pradip K; Zang, Qin et al. (2016) Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides. ACS Comb Sci 18:387-93
Gowthaman, Ragul; Miller, Sven A; Rogers, Steven et al. (2016) DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites. J Med Chem 59:4152-70
Faisal, Saqib; Maity, Pradip K; Zang, Qin et al. (2016) Synthesis of High-Load, Hybrid Silica-Immobilized Heterocyclic Benzyl Phosphate (Si-OHBP) and Triazolyl Phosphate (Si-OHTP) Alkylating Reagents. ACS Comb Sci 18:394-8
Loh, Joanna K; Asad, Naeem; Samarakoon, Thiwanka B et al. (2015) Modular, One-Pot, Sequential Aziridine Ring Opening-S(N)Ar Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams. J Org Chem 80:9926-41

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