Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM069721-10
Application #
8144392
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
10
Fiscal Year
2010
Total Cost
$475,149
Indirect Cost
Name
Broad Institute, Inc.
Department
Type
DUNS #
623544785
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Gerard, Baudouin; O'Shea, Morgan Welzel; Donckele, Etienne et al. (2014) Correction to Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library. ACS Comb Sci 16:46
Bergonzini, Giulia; Schindler, Corinna S; Wallentin, Carl-Johan et al. (2014) Photoredox Activation and Anion Binding Catalysis in the Dual Catalytic Enantioselective Synthesis of ?-Amino Esters. Chem Sci 5:
Wawer, Mathias J; Li, Kejie; Gustafsdottir, Sigrun M et al. (2014) Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proc Natl Acad Sci U S A 111:10911-6
Over, Björn; McCarren, Patrick; Artursson, Per et al. (2014) Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties. J Med Chem 57:2746-54
Xu, Hao; Zhang, Hu; Jacobsen, Eric N (2014) Chiral sulfinamidourea and strong Brønsted acid-cocatalyzed enantioselective Povarov reaction to access tetrahydroquinolines. Nat Protoc 9:1860-6
Wawer, Mathias J; Jaramillo, David E; Dan?ík, Vlado et al. (2014) Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. J Biomol Screen 19:738-48
Frumm, Stacey M; Fan, Zi Peng; Ross, Kenneth N et al. (2013) Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem Biol 20:713-25
Rajapaksa, Naomi S; McGowan, Meredeth A; Rienzo, Matthew et al. (2013) Enantioselective total synthesis of (+)-reserpine. Org Lett 15:706-9
Wang, Yikai; Jimenez, Miguel; Sheehan, Patrick et al. (2013) Selective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes. Org Lett 15:1218-21
Lalonde, Mathieu P; McGowan, Meredeth A; Rajapaksa, Naomi S et al. (2013) Enantioselective formal aza-Diels-Alder reactions of enones with cyclic imines catalyzed by primary aminothioureas. J Am Chem Soc 135:1891-4

Showing the most recent 10 out of 71 publications