PROJECT 1 - INTRACELLULAR NETWORKS. Project Leader: J. Broach (Molbio) Six research groups in the Center work on distinct examples of intracellular networks. In all cases the approach to modeling a signaling network consists of a joint effort of experimental biologists and mathematically oriented theorists. The dynamic interplay between the experimentalists and the theorists occurs on a daily basis and is made possible by the close physical proximity and the collaborative mind set (see Figure 1) of everyone associated with the Center. In addition, all the groups draw heavily on the core facilities of the Center;microarray, mass spectrometry and imaging facilities provide the experimentalists with the means of acquiring requisite quantitative data and the computational core provides a means of storing and analyzing those data. Two fundamental problems in cellular biology are being addressed: transcriptional networks (i.e. defining and analyzing how cells coordinate their complex transcriptional changes that occur under changing environments, and coordination of cell growth (i.e. how cells manage to maintain balanced growth over a wide range of growth rates and environmental perturbations).
| Lee, Ha Neul; Mitra, Mithun; Bosompra, Oye et al. (2018) RECK isoforms have opposing effects on cell migration. Mol Biol Cell 29:1825-1838 |
| Garcia, Hernan G; Gregor, Thomas (2018) Live Imaging of mRNA Synthesis in Drosophila. Methods Mol Biol 1649:349-357 |
| Mitra, Mithun; Johnson, Elizabeth L; Swamy, Vinay S et al. (2018) Alternative polyadenylation factors link cell cycle to migration. Genome Biol 19:176 |
| Gibney, Patrick A; Schieler, Ariel; Chen, Jonathan C et al. (2018) Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Mol Biol Cell 29:897-910 |
| Mitra, Mithun; Lee, Ha Neul; Coller, Hilary A (2018) Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts. J Vis Exp : |
| Lee, Andrew H; Dhingra, Satish K; Lewis, Ian A et al. (2018) Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. Sci Rep 8:13578 |
| Sanchez, Monica R; Miller, Aaron W; Liachko, Ivan et al. (2017) Differential paralog divergence modulates genome evolution across yeast species. PLoS Genet 13:e1006585 |
| Matheson, Kinnari; Parsons, Lance; Gammie, Alison (2017) Whole-Genome Sequence and Variant Analysis of W303, a Widely-Used Strain of Saccharomyces cerevisiae. G3 (Bethesda) 7:2219-2226 |
| Painter, Heather J; Carrasquilla, Manuela; Llinás, Manuel (2017) Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum. Genome Res 27:1074-1086 |
| Smukowski Heil, Caiti S; DeSevo, Christopher G; Pai, Dave A et al. (2017) Loss of Heterozygosity Drives Adaptation in Hybrid Yeast. Mol Biol Evol 34:1596-1612 |
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