Abstract

ECC Unit 3 Mathematical/Simulation Unit - This unit will be located in New York and distributed between Mount Sinai and NYU Courant. Only software development will be done at NCBS in Bangalore India under the leadership of Upi Bhalla. Progress in the study of physioloigcal regulatory systems has advanced to a stage where closely associated theoretical research is required. Mathematics coupled with computational simulations provides the ideal framework for this endeavor. Mathematics allows for the development of theoretical models of biological systems that can generate predictions and suggest experimental tests to either confirm or refute the models. All four of the research projects in the SBC will use computational modeling as a means of developing hypotheses and understanding experimental data. Mathematical techniques can also be used to organize and interpret experimental data, particularly in this era in which high-throughput techniques produce extremely large data sets. These observations provide compelling arguments for a mathematics/simulation unit with the ECC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM071558-05
Application #
8323253
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
5
Fiscal Year
2011
Total Cost
$224,726
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Jones, DeAnalisa C; Gong, Jingqi Q X; Sobie, Eric A (2018) A privileged role for neuronal Na+ channels in regulating ventricular [Ca2+] and arrhythmias. J Gen Physiol 150:901-905
Barrette, Anne Marie; Bouhaddou, Mehdi; Birtwistle, Marc R (2018) Integrating Transcriptomic Data with Mechanistic Systems Pharmacology Models for Virtual Drug Combination Trials. ACS Chem Neurosci 9:118-129
Xiong, Yuguang; Soumillon, Magali; Wu, Jie et al. (2017) A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries. Sci Rep 7:14626
Falkenberg, Cibele V; Azeloglu, Evren U; Stothers, Mark et al. (2017) Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability. PLoS Comput Biol 13:e1005433
Gong, Jingqi Q X; Shim, Jaehee V; Núñez-Acosta, Elisa et al. (2017) I love it when a plan comes together: Insight gained through convergence of competing mathematical models. J Mol Cell Cardiol 102:31-33
Hansen, Jens; Meretzky, David; Woldesenbet, Simeneh et al. (2017) A flexible ontology for inference of emergent whole cell function from relationships between subcellular processes. Sci Rep 7:17689
Stern, Alan D; Rahman, Adeeb H; Birtwistle, Marc R (2017) Cell size assays for mass cytometry. Cytometry A 91:14-24
Stillitano, Francesca; Hansen, Jens; Kong, Chi-Wing et al. (2017) Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife 6:
Ron, Amit; Azeloglu, Evren U; Calizo, Rhodora C et al. (2017) Cell shape information is transduced through tension-independent mechanisms. Nat Commun 8:2145
Flamini, Vittoria; DeAnda, Abe; Griffith, Boyce E (2016) Immersed boundary-finite element model of fluid-structure interaction in the aortic root. Theor Comput Fluid Dyn 30:139-164

Showing the most recent 10 out of 185 publications