Abstract

The UCSF Center for Systems and Synthetic Biology is focused on understanding how cells make decisions using genetically encoded molecular networks. To achieve this goal, we have assembled a diverse group of scientists from different fields who bring different perspectives.
The aims of the Administrative Core are to provide an organizational structure that facilitates our research goals by breaking down barriers between our investigators, creating a strong and interactive community, and recruiting talented young Fellows to our Center. We also aim to disseminate our tools and research to the broader UCSF community, through the organization of local meetings, symposia, and workshops. Finally, we also aim to disseminate the ideas that emerge from our Center through extensive educational outreach and materials ranging from K-12 to graduate education. The administrative core plays an essential role in allowing us to most effectively achieve our goals and disseminate our ideas and findings. LEAD PI: LIM PI's: LIM, EL-SAMAD

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM081879-07
Application #
9339702
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2010-09-01
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
7
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118

  Publications

Bugaj, L J; Sabnis, A J; Mitchell, A et al. (2018) Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science 361:
Obernier, Kirsten; Cebrian-Silla, Arantxa; Thomson, Matthew et al. (2018) Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation. Cell Stem Cell 22:221-234.e8
Toda, Satoshi; Blauch, Lucas R; Tang, Sindy K Y et al. (2018) Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science 361:156-162
Aranda-Díaz, Andrés; Mace, Kieran; Zuleta, Ignacio et al. (2017) Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast. ACS Synth Biol 6:545-554
Lim, Wendell A; June, Carl H (2017) The Principles of Engineering Immune Cells to Treat Cancer. Cell 168:724-740
Nissen, Kelly E; Homer, Christina M; Ryan, Colm J et al. (2017) The histone variant H2A.Z promotes splicing of weak introns. Genes Dev 31:688-701
Kim, Ji-Wook; Seo, Daeha; Lee, Jung-Uk et al. (2017) Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc 12:1871-1889
Lechler, Marie C; Crawford, Emily D; Groh, Nicole et al. (2017) Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging. Cell Rep 18:454-467
Wilson, Maxwell Z; Ravindran, Pavithran T; Lim, Wendell A et al. (2017) Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell 67:757-769.e5
Datta, Anirban; Sandilands, Emma; Mostov, Keith E et al. (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cell Signal 40:91-98

Showing the most recent 10 out of 183 publications