Abstract

Biology is the study of complex systems whose components are regulated not only in their ability to interact, but at the level of their synthesis and degradation. Interdependencies between components in both types of reactions are the norm rather than the exception. A hallmark of Systems Biology is the focus on understanding the behavior of the biological system following the identification of all relevant components. Mathematical modeling has been essential in other complex Systems studies, and has been successfully applied to biological systems at many different scales to elucidate systems emergent properties in many different applications. However, key challenges remain in making mathematical modeling approaches as impactful in biology as it ought to be. These challenges are conceptual, technical, and cultural. The Mathematical Modeling Core will address barriers that have hindered the widespread incorporation of modeling tools into biomedical research through a series of Research Activities and Service Activities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM085764-04
Application #
8538448
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$151,973
Indirect Cost
$54,200

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Zhang, Wei; Ma, Jianzhu; Ideker, Trey (2018) Classifying tumors by supervised network propagation. Bioinformatics 34:i484-i493
Xiong, Liyang; Cooper, Robert; Tsimring, Lev S (2018) Coexistence and Pattern Formation in Bacterial Mixtures with Contact-Dependent Killing. Biophys J 114:1741-1750
Cooper, Robert; Tsimring, Lev; Hasty, Jeff (2018) Microfluidics-Based Analysis of Contact-dependent Bacterial Interactions. Bio Protoc 8:
Martinez-Corral, Rosa; Liu, Jintao; Süel, Gürol M et al. (2018) Bistable emergence of oscillations in growing Bacillus subtilis biofilms. Proc Natl Acad Sci U S A 115:E8333-E8340
Zhang, Wei; Bojorquez-Gomez, Ana; Velez, Daniel Ortiz et al. (2018) A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. Nat Genet 50:613-620
Dai, Xiongfeng; Zhu, Manlu; Warren, Mya et al. (2018) Slowdown of Translational Elongation in Escherichia coli under Hyperosmotic Stress. MBio 9:
Muse, Evan D; Yu, Shan; Edillor, Chantle R et al. (2018) Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. Proc Natl Acad Sci U S A 115:E4680-E4689
Bui, Nam; Huang, Justin K; Bojorquez-Gomez, Ana et al. (2018) Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. Mol Cancer Ther 17:1585-1594
Huang, Justin K; Carlin, Daniel E; Yu, Michael Ku et al. (2018) Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. Cell Syst 6:484-495.e5
Ozturk, Kivilcim; Dow, Michelle; Carlin, Daniel E et al. (2018) The Emerging Potential for Network Analysis to Inform Precision Cancer Medicine. J Mol Biol 430:2875-2899

Showing the most recent 10 out of 207 publications