We propose to study event-related potential: (ERPS) and performance measures to delineate attentional dysfunction in Attention-deficit Hyperactivity Disorder (ADHD) adolescents. We will explore the extent of differences in the prevalence of deficits in processing varying degrees of cognitive load and demands of selective attention among ADHD patients identified in childhood a: having ADHD with hyperactivity as well as inattentiveness (ADHD/Combined Type), ADHD without hyperactivity (ADHD/Inattentive Type), ADHD/Combined Type with reading disorder (RD) ADHD/Inattentive Type with (RD), and RD without ADHD. Male: and files in each group will be sampled in sufficient numbers in order to examine hitherto neglected sex differences. In order to evaluate the differential impact of pharmacological therapy on these clinical populations we will study all these subjects in a double-blind challenge with methylphenidate (0.5 mg/Kg) and placebo. This research will provide information on the extent of impact of stimulants on attentional function among various forms of the ADHD syndrome. We will also test normal adolescents without medication, so that we can determine the extent to which the ADHD and RD samples attentional functions are normal.
| Estrada, Eduardo; Ferrer, Emilio; Shaywitz, Bennett A et al. (2018) Identifying atypical change at the individual level from childhood to adolescence. Dev Psychol 54:2193-2206 |
| Lebel, Catherine; Shaywitz, Bennett; Holahan, John et al. (2013) Diffusion tensor imaging correlates of reading ability in dysfluent and non-impaired readers. Brain Lang 125:215-22 |
| Ferrer, Emilio; Shaywitz, Bennett A; Holahan, John M et al. (2010) Uncoupling of reading and IQ over time: empirical evidence for a definition of dyslexia. Psychol Sci 21:93-101 |
| Shaywitz, Sally E; Shaywitz, Bennett A (2008) Paying attention to reading: the neurobiology of reading and dyslexia. Dev Psychopathol 20:1329-49 |
| Shaywitz, Sally E; Morris, Robin; Shaywitz, Bennett A (2008) The education of dyslexic children from childhood to young adulthood. Annu Rev Psychol 59:451-75 |
| Noble, Kimberly G; McCandliss, Bruce D; Farah, Martha J (2007) Socioeconomic gradients predict individual differences in neurocognitive abilities. Dev Sci 10:464-80 |
| Shaywitz, Sally E; Gruen, Jeffrey R; Shaywitz, Bennett A (2007) Management of dyslexia, its rationale, and underlying neurobiology. Pediatr Clin North Am 54:609-23, viii |
| Shaywitz, Bennett A; Skudlarski, Pawel; Holahan, John M et al. (2007) Age-related changes in reading systems of dyslexic children. Ann Neurol 61:363-70 |
| Burgio-Murphy, Andrea; Klorman, Rafael; Shaywitz, Sally E et al. (2007) Error-related event-related potentials in children with attention-deficit hyperactivity disorder, oppositional defiant disorder, reading disorder, and math disorder. Biol Psychol 75:75-86 |
| Noble, Kimberly G; Wolmetz, Michael E; Ochs, Lisa G et al. (2006) Brain-behavior relationships in reading acquisition are modulated by socioeconomic factors. Dev Sci 9:642-54 |
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