The Colorado Learning Disabilities Research Center (CLDRC) is a long-standing interdisciplinary, multisite research program that investigates the genetic and environmental etiologies, neurobiology, neuropsychology, classification, and outcomes of learning disabilities (LDs) and related disorders such as attention/deficit- hyperactivity disorder (ADHD). The overarching long-term goal of the CLDRC is to develop and refine a comprehensive neurodevelopmental and neurobiological model of LDs and related disorders, then to use that model to inform early screening and identification to guide prevention and treatment. Results from the CLDRC will facilitate refinements to theoretical models and improve classification of learning disabilities (LDs) and lead to important improvements in neural models of LDs and related disorders, including the cognitive correlates of LDs in the understudied population of bilingual learners. In combination with the results from the other projects, the molecular genetic analyses in Project IV will provide key information to develop and refine etiological models of the specific genetic and environmental risk factors that contribute to the development of LDs. Of similar importance to these research objectives are our related aims regarding the effective dissemination of our results. In addition to our ongoing efforts to publish our result for the scientific community, the Engagement Core will support efforts to translate and disseminate results from the CLDRC to a broader audiences of practitioners, educators, and individuals with learning disabilities. The CLDRC infrastructure also provides an unprecedented opportunity for interdisciplinary mentorship and project-embedded career enhancement opportunities for the next generation of LD investigators. We will continue to support these opportunities during the next five years through individual training plans, a new CLDRC webinar series, and the CLDRC Pilot Project Program, helping to ensure that the developing scholars in the CLDRC are highly competitive for positions in top-tier research universities when they leave our laboratories and training programs. The most distal long-term research objective of the CLDRC is the development of a comprehensive model of LDs that is based on a complete understanding of LDs at the genetic, environmental, neurobiological, cognitive, behavioral, and instructional levels of analysis. This is a daunting challenge that cannot be overcome by a single scientist or research lab working in isolation. Instead, this work will require the successful integration of diverse literatures, scientific approaches, and analytical strategies. The ongoing and long-term objective of the CLDRC is to continue provide a place where this integration can occur to promote interdisciplinary LD research and to develop the next generation of interdisciplinary scientists and practitioners.

Public Health Relevance

The Colorado Learning Disabilities Research Center is a long-standing interdisciplinary, multisite research program that investigates the genetic and environmental etiologies, neurobiology, neuropsychology, classification, and outcomes of learning disabilities (LDs) and related disorders such as attention/deficit- hyperactivity disorder (ADHD).

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
2P50HD027802-26
Application #
9406410
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Miller, Brett
Project Start
1996-12-01
Project End
2022-07-31
Budget Start
2017-09-28
Budget End
2018-07-31
Support Year
26
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80303
McGrath, Lauren M (2018) Two GWASs Are Better Than One: Enhancing Genetic Discovery for Developmental Phenotypes. J Am Acad Child Adolesc Psychiatry 57:77-79
Leopold, Daniel R; Christopher, Micaela E; Olson, Richard K et al. (2018) Invariance of ADHD Symptoms Across Sex and Age: a Latent Analysis of ADHD and Impairment Ratings from Early Childhood into Adolescence. J Abnorm Child Psychol :
Aboud, Katherine S; Barquero, Laura A; Cutting, Laurie E (2018) Prefrontal mediation of the reading network predicts intervention response in dyslexia. Cortex 101:96-106
Ricker, Ashley A; Corley, Robin; DeFries, John C et al. (2018) Examining the influence of perceived stress on developmental change in memory and perceptual speed for adopted and nonadopted individuals. Dev Psychol 54:138-150
DeMille, Mellissa M C; Tang, Kevin; Mehta, Chintan M et al. (2018) Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages. Proc Natl Acad Sci U S A 115:4951-4956
Wilkey, Eric D; Cutting, Laurie E; Price, Gavin R (2018) Neuroanatomical correlates of performance in a state-wide test of math achievement. Dev Sci 21:
Devanna, P; Chen, X S; Ho, J et al. (2018) Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders. Mol Psychiatry 23:1375-1384
Frijters, Jan C; Tsujimoto, Kimberley C; Boada, Richard et al. (2018) Reading-Related Causal Attributions for Success and Failure: Dynamic Links With Reading Skill. Read Res Q 53:127-148
Peterson, Robin L; Arnett, Anne B; Pennington, Bruce F et al. (2018) Literacy acquisition influences children's rapid automatized naming. Dev Sci 21:e12589
Becker, Stephen P; Willcutt, Erik G (2018) Advancing the study of sluggish cognitive tempo via DSM, RDoC, and hierarchical models of psychopathology. Eur Child Adolesc Psychiatry :

Showing the most recent 10 out of 201 publications