The mission of the proposed Center for Genetics Research Ethics and Law (CGREL) is to foster sustained interdisciplinary research on the ethical, legal, and social issues involved in the design and conduct of human genetics research with individuals, families, communities, and populations. CWRU already hosts a variety of research efforts relevant to the CGREL's theme. The CGREL will integrate these efforts to launch new research collaborations and provide the resource structure necessary for their application to high priority genetics research policy questions. The basic architecture of the CGREL consists of six overlapping research groups, six research resource cores, and a research training program. The research collaborations generated by the CGREL will be harnessed to pursue four Center-Wide research aims, which we believe reflect the highest priority needs in genetic research ethics and policymaking: 1. To improve our understanding of the relationship between human genetics research and the humans it seeks to benefit by elucidating the cultural values and beliefs that influence different people's reactions to and experience of genetics research participation. 2. To improve our understanding of the relationship between human genetics research and the human benefits it promises by elucidating the influence of translational incentives, ranging from commercial prospects to benefit-sharing agreements, on the design and conduct of basic genetics research. 3. To anticipate the research ethics and science policy issues raised by new advances in genetics research by analyzing the confluence of human variation research, computational genomics, sequencing technologies, and gene transfer techniques through the lenses of contemporary research regulations and norms. 4. To harness ongoing scholarship on genetics research ethics for practical application by providing evidence-based policy options for use by the scientific community, institutional review boards, and national research regulatory bodies in seeking to improve participant protections in the design and conduct of human genetic research.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center (P50)
Project #
5P50HG003390-03
Application #
7104879
Study Section
Special Emphasis Panel (ZHG1-HGR-P (M1))
Program Officer
Boyer, Joy
Project Start
2004-09-01
Project End
2009-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
3
Fiscal Year
2006
Total Cost
$1,050,608
Indirect Cost
Name
Case Western Reserve University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Meagher, Karen M; McGowan, Michelle L; Settersten Jr, Richard A et al. (2017) Precisely Where Are We Going? Charting the New Terrain of Precision Prevention. Annu Rev Genomics Hum Genet 18:369-387
McGowan, Michelle L; Ponsaran, Roselle S; Silverman, Paula et al. (2016) ""A rising tide lifts all boats"": establishing a multidisciplinary genomic tumor board for breast cancer patients with advanced disease. BMC Med Genomics 9:71
Mester, Jessica L; Mercer, MaryBeth; Goldenberg, Aaron et al. (2015) Communicating with biobank participants: preferences for receiving and providing updates to researchers. Cancer Epidemiol Biomarkers Prev 24:708-12
Lázaro-Muñoz, Gabriel; Conley, John M; Davis, Arlene M et al. (2015) Response to Open Peer Commentaries on ""Looking for Trouble: Preventive Genomic Sequencing in the General Population and the Role of Patient Choice"". Am J Bioeth 15:W6-9
Hartmann, Christopher D; Marshall, Patricia A; Goldenberg, Aaron J (2015) Is there a space for place in family history assessment? Underserved community views on the impact of neighborhood factors on health and prevention. J Prim Prev 36:119-30
Burke, Wylie; Appelbaum, Paul; Dame, Lauren et al. (2015) The translational potential of research on the ethical, legal, and social implications of genomics. Genet Med 17:12-20
Marshall, Patricia A; Adebamowo, Clement A; Adeyemo, Adebowale A et al. (2014) Voluntary participation and comprehension of informed consent in a genetic epidemiological study of breast cancer in Nigeria. BMC Med Ethics 15:38
Henderson, Gail E; Wolf, Susan M; Kuczynski, Kristine J et al. (2014) The challenge of informed consent and return of results in translational genomics: empirical analysis and recommendations. J Law Med Ethics 42:344-55
de Vries, Jantina; Abayomi, Akin; Brandful, James et al. (2014) A perpetual source of DNA or something really different: ethical issues in the creation of cell lines for African genomics research. BMC Med Ethics 15:60
Goldenberg, Aaron J; Dodson, Daniel S; Davis, Matthew M et al. (2014) Parents' interest in whole-genome sequencing of newborns. Genet Med 16:78-84

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