DNA sequencing is arguably the core technology at the heart of genomics. The idea of having a reference sequence of the human genome grew out of the Sanger-Coulson and Maxam-Gilbert sequencing technologies developed in the 1970s.[62] The history of DNA sequencing is of considerable interest in its own right. That history is also important to understand the academic-industrial-government ecosystem in which genomics takes place, and to inform policy choices about future genomic technologies. This Project will carry forward the work started in CpG 1.0 on DNA sequencing technologies and norms of sharing data that took root in different subfields of genomics. It will then look ahead to full-genome sequence analysis of individuals as it gets faster, cheaper, and more widely used in both clinical medicine and personal genomics. A central question is whether the use of DNA sequencing technology might be constrained by existing DNA patents. This Project will draw on the legal scholarship in Projects 1 and 2 (Rai, Reichman), with implications for Project 6 (Angrist).
| Cook-Deegan, Robert; Ankeny, Rachel A; Maxson Jones, Kathryn (2017) Sharing Data to Build a Medical Information Commons: From Bermuda to the Global Alliance. Annu Rev Genomics Hum Genet 18:389-415 |
| Cook-Deegan, Robert; McGuire, Amy L (2017) Moving beyond Bermuda: sharing data to build a medical information commons. Genome Res 27:897-901 |
| Thorogood, Adrian; Cook-Deegan, Robert; Knoppers, Bartha Maria (2017) Public variant databases: liability? Genet Med 19:838-841 |
| Cook-Deegan, Robert; Vishnubhakat, Saurabh; Bubela, Tania (2016) The mouse that trolled (again). J Law Biosci 3:185-191 |
| Michie, Marsha; Kraft, Stephanie A; Minear, Mollie A et al. (2016) Informed decision-making about prenatal cfDNA screening: An assessment of written materials. Ethics Med Public Health 2:362-371 |
| Meredith, Stephanie; Kaposy, Christopher; Miller, Victoria J et al. (2016) Impact of the increased adoption of prenatal cfDNA screening on non-profit patient advocacy organizations in the United States. Prenat Diagn 36:714-9 |
| Minear, Mollie A; Lewis, Celine; Pradhan, Subarna et al. (2015) Global perspectives on clinical adoption of NIPT. Prenat Diagn 35:959-67 |
| Angrist, Misha (2015) Start me up: ways to encourage sharing of genomic information with research participants. Nat Rev Genet 16:435-6 |
| Burke, Wylie; Appelbaum, Paul; Dame, Lauren et al. (2015) The translational potential of research on the ethical, legal, and social implications of genomics. Genet Med 17:12-20 |
| Minear, Mollie A; Alessi, Stephanie; Allyse, Megan et al. (2015) Noninvasive Prenatal Genetic Testing: Current and Emerging Ethical, Legal, and Social Issues. Annu Rev Genomics Hum Genet 16:369-98 |
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