Abstract

A diverse group of investigators including cardiac physiologists, cardiac surgeons, radiologists, pathologists, biochemists, and immunologists propose to attack the problem of ischemic heart disease both from a fundamental and an applied direction. Studies range from the mechanism of ischemic injury of tissue at a cellular or molecular level to the diagnosis and control of ischemic injury in man.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL026215-07
Application #
3106617
Study Section
(SRC)
Project Start
1980-01-01
Project End
1989-09-29
Budget Start
1985-09-30
Budget End
1986-09-29
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Osswald, S; Wilber, D J; Lin, J L et al. (1997) Mechanisms underlying different surface ECG morphologies of recurrent monomorphic ventricular tachycardia and their modification by procainamide. J Cardiovasc Electrophysiol 8:11-23
Davidoff, R; Picard, M H; Force, T et al. (1994) Spatial and temporal variability in the pattern of recovery of ventricular geometry and function after acute occlusion and reperfusion. Am Heart J 127:1231-41
Neubauer, S; Newell, J B; Ingwall, J S (1992) Metabolic consequences and predictability of ventricular fibrillation in hypoxia. A 31P- and 23Na-nuclear magnetic resonance study of the isolated rat heart. Circulation 86:302-10
Okada, R D; Murphy, J H; Boucher, C A et al. (1992) Relationship between septal perfusion, viability, and motion before and after coronary artery bypass surgery. Am Heart J 124:1190-5
Picard, M H; Wilkins, G T; Ray, P A et al. (1992) Progressive changes in ventricular structure and function during the year after acute myocardial infarction. Am Heart J 124:24-31
Esumi, K; Nishida, M; Shaw, D et al. (1991) NADH measurements in adult rat myocytes during simulated ischemia. Am J Physiol 260:H1743-52
Hagar, J M; Hale, S L; Ilvento, J P et al. (1991) Lack of significant effects of superoxide dismutase and catalase on development of reperfusion arrhythmias. Basic Res Cardiol 86:127-35
Lin, J L; Wilber, D J; Du, D et al. (1991) Localization of breakthrough site of canine monomorphic ventricular tachycardia by pacemapping. A vectorial approach. Circulation 84:1319-32
Picard, M H; Wilkins, G T; Gillam, L D et al. (1991) Immediate regional endocardial surface expansion following coronary occlusion in the canine left ventricle: disproportionate effects of anterior versus inferior ischemia. Am Heart J 121:753-62
Przyklenk, K; Kloner, R A (1991) Angiotensin converting enzyme inhibitors improve contractile function of stunned myocardium by different mechanisms of action. Am Heart J 121:1319-30

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