Our overall goal is to continue to produce new knowledge of the regulation of lung growth from fetal life through adolescence. In Project 1, Smith et al will pursue purification and synthesis of fibroblast pneumonocyte factor. The role of growth factors and hormones in alveolar cell maturation will be pursued. In Project 3, Taeusch and Phelps plan to evaluate the role of surfactant associated proteins. Further isolation, purification, and functional evaluation are underway. Surfactant replacement will be pursued, with reference to the best method of distribution, study of batch to batch variability of TA surfactant, and definition of lower age group that might be expected to respond. Work on lung mechanics will take new directions as Fredberg assumes leadership of the group studying the mechanism of high frequency ventilation and Frantz pursues an NIH sponsored clinical trial. Stark et al will investigate the role of the diaphragm and larynx in maintenance of lung volume in infants. Wohl, Castile et al will follow the infants who had combinations of preterm birth and lung injury with respect to later lung growth. Infants who received surfactant replacement in the 1984-85 study will be recruited into pulmonary and neurologic and immunologic follow up studies.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL034616-06
Application #
3106741
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1981-09-15
Project End
1991-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Richardson, D K; Torday, J S (1994) Racial differences in predictive value of the lecithin/sphingomyelin ratio. Am J Obstet Gynecol 170:1273-8
Guttentag, S H; Phelps, D S; Warshaw, J B et al. (1992) Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats. Am J Respir Cell Mol Biol 7:190-7
Eichenwald, E C; Howell 3rd, R G; Kosch, P C et al. (1992) Developmental changes in sequential activation of laryngeal abductor muscle and diaphragm in infants. J Appl Physiol 73:1425-31
Guttentag, S H; Phelps, D S; Stenzel, W et al. (1992) Surfactant protein A expression is delayed in fetuses of streptozotocin-treated rats. Am J Physiol 262:L489-94
Guttentag, S H; Phelps, D S; Floros, J (1992) Surfactant protein regulation and diabetic pregnancy. Semin Perinatol 16:122-9
Torday, J (1992) Cellular timing of fetal lung development. Semin Perinatol 16:130-9
Boynton, B R; Barnas, G M; Dadmun, J T et al. (1991) Mechanical coupling of the rib cage, abdomen, and diaphragm through their area of apposition. J Appl Physiol 70:1235-44
Boynton, B R; Villanueva, D; Hammond, M D et al. (1991) Effect of mean airway pressure on gas exchange during high-frequency oscillatory ventilation. J Appl Physiol 70:701-7
Chida, S; Phelps, D S; Soll, R F et al. (1991) Surfactant proteins and anti-surfactant antibodies in sera from infants with respiratory distress syndrome with and without surfactant treatment. Pediatrics 88:84-9
Phelps, D S; Floros, J (1991) Dexamethasone in vivo raises surfactant protein B mRNA in alveolar and bronchiolar epithelium. Am J Physiol 260:L146-52

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