Abstract

The Laboratory Animal Core C will manage and facilitate the use of animal resources in our group of interacting SCOR laboratories. By combining animal ordering in a single centrally managed core, it should be possible to utilize these resources more efficiently, and minimize the number of animals required. For example, neonatal rabbits are utilized in several projects, and the animal core will allow needs to be anticipated so that maternal rabbits can be bred at Rochester in the most cost effective fashion, with less stress than typical with transported pregnant rabbits.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL036543-10
Application #
5213599
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

D'Angio, Carl T; Sinkin, Robert A; Stevens, Timothy P et al. (2002) Longitudinal, 15-year follow-up of children born at less than 29 weeks' gestation after introduction of surfactant therapy into a region: neurologic, cognitive, and educational outcomes. Pediatrics 110:1094-102
D'Angio, Carl T; Basavegowda, Kumar; Avissar, Nelly E et al. (2002) Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants. Biol Neonate 82:145-9
Phipps, R P; Kaufman, J; Blumberg, N (2001) Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet 357:2023-4
Sinkin, R A; Dweck, H S; Horgan, M J et al. (2000) Early dexamethasone-attempting to prevent chronic lung disease. Pediatrics 105:542-8
O'Reilly, M A; Staversky, R J; Watkins, R H et al. (2000) p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol 278:L552-9
O'Reilly, M A; Staversky, R J; Huyck, H L et al. (2000) Bcl-2 family gene expression during severe hyperoxia induced lung injury. Lab Invest 80:1845-54
Charafeddine, L; D'Angio, C T; Phelps, D L (1999) Atypical chronic lung disease patterns in neonates. Pediatrics 103:759-65
Watkins, R H; D'Angio, C T; Ryan, R M et al. (1999) Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury. Am J Physiol 276:L858-67
D'Angio, C T; Maniscalco, W M; Ryan, R M et al. (1999) Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone. Biol Neonate 76:266-73
D'Angio, C T; LoMonaco, M B; Chaudhry, S A et al. (1999) Discordant pulmonary proinflammatory cytokine expression during acute hyperoxia in the newborn rabbit. Exp Lung Res 25:443-65

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