Core - Coordinating Core

Tsao, Francis H C.

Abstract

Core Unit C is responsible for coordinating essential aspects of both basic and clinical research and for the productivity of projects that depend upon either cultured type II pneumocytes or the entry of human subjects (i.e., premature infants) in clinical protocols. This Core will provide centralized research support services in an efficient, cost-effective fashion--allowing investigators to optimize their efforts with individual and collaborative research projects. Core Unit C will serve all four research projects with highly skilled personnel such as a pediatric research nurse and a dedicated cell culture technician--thereby facilitating the scientific efforts of all responsible investigators.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Specialized Center (P50)
• Project #: 5P50HL046478-05
• Application #: 5213879
• Support Year: 5
• Fiscal Year: 1996

Publications

Grummer, M A; Zachman, R D (1998) Retinoic acid and dexamethasone affect RAR-beta and surfactant protein C mRNA in the MLE lung cell line. Am J Physiol 274:L1-7

Tsao, F H; Meyer, K C; Chen, X et al. (1998) Degradation of annexin I in bronchoalveolar lavage fluid from patients with cystic fibrosis. Am J Respir Cell Mol Biol 18:120-8

Zimmerman, J J; Gabbert, D; Shivpuri, C et al. (1998) Meter-dosed, inhaled beclomethasone attenuates bronchoalveolar oxyradical inflammation in premature infants at risk for bronchopulmonary dysplasia. Am J Perinatol 15:567-76

Zachman, R D; Grummer, M A (1998) Effect of maternal/fetal vitamin A deficiency on fetal rat lung surfactant protein expression and the response to prenatal dexamethasone. Pediatr Res 43:178-83

Ts'ao, C; Ward, W F; Molteni, A et al. (1997) Annexin I concentration and prostacyclin production in rat lung and alveolar macrophages following irradiation. Prostaglandins Leukot Essent Fatty Acids 56:99-104

Zimmerman, J J; Ciesielski, W; Lewandoski, J (1997) Neutrophil-mediated phospholipid peroxidation assessed by gas chromatography-mass spectroscopy. Am J Physiol 273:C653-61

Contreras, M; Hariharan, N; Lewandoski, J R et al. (1996) Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia. Crit Care Med 24:29-37

Tsao, F H; Cheng, W; Chen, X et al. (1996) Isolation and sequencing of the cDNA encoding phosphatidylinositol transfer protein from rabbit lung. Gene 172:299-302

Zachman, R D; Samuels, D P; Brand, J M et al. (1996) Use of the intramuscular relative-dose-response test to predict bronchopulmonary dysplasia in premature infants. Am J Clin Nutr 63:123-9

Zimmerman, J J (1995) Bronchoalveolar inflammatory pathophysiology of bronchopulmonary dysplasia. Clin Perinatol 22:429-56