Abstract

The goal of this proposal is to develop basic and clinical insights that can serve as the basis for improved therapies for patients with acute lung injury. To accomplish this, we have developed a program that unifies investigators from throughout the University of Minnesota academic community. Our proposal has 4 key elements: 1) Five Research Projects featuring basic and clinical investigation in molecular biology, cell biology, biochemistry, an physiology directed at elucidating fundamental mechanisms of lung repair; 2) a Clinical Core that coordinates clinical research with the care of more than 100 patients with adult respiratory failure annually; 3) a Morphology and Cell Culture Core to facilitate uniform, high quality analysis and maintenance of tissue and cell culture preparations; and 4) an Administrative Core to coordinate the successful operation of the SCOR. Our focus in the current application will be lung repair, because this theme scientifically unites the 5 component projects proposed into an integrated collective. Each of the 5 projects in the current proposal will examine aspects of the cellular, molecular and physiological processes, involved in the resolution and repair of lung injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
1P50HL050152-01
Application #
2226252
Study Section
Special Emphasis Panel (ZHL1-CSR-B (M2))
Project Start
1993-12-30
Project End
1998-11-30
Budget Start
1993-12-30
Budget End
1994-11-30
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Larsson, Ola; Perlman, David M; Fan, Danhua et al. (2006) Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Res 34:4375-86
Li, Shunan; Perlman, David M; Peterson, Mark S et al. (2004) Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis. J Biol Chem 279:21312-7
Lei, Jianxun; Mariash, Cary N; Ingbar, David H (2004) 3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent. J Biol Chem 279:47589-600
Lee, S Y; Maniak, P J; Rhodes, R et al. (2003) Basolateral Cl- transport is stimulated by terbutaline in adult rat alveolar epithelial cells. J Membr Biol 191:133-9
Tian, Bin; Han, Lei; Kleidon, Jill et al. (2003) An HSV-TK transgenic mouse model to evaluate elimination of fibroblasts for fibrosis therapy. Am J Pathol 163:789-801
Lee, So Yeong; Maniak, Peter J; Ingbar, David H et al. (2003) Adult alveolar epithelial cells express multiple subtypes of voltage-gated K+ channels that are located in apical membrane. Am J Physiol Cell Physiol 284:C1614-24
Lei, Jianxun; Nowbar, Sogol; Mariash, Cary N et al. (2003) Thyroid hormone stimulates Na-K-ATPase activity and its plasma membrane insertion in rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 285:L762-72
Li, Shunan; Takasu, Tasaburo; Perlman, David M et al. (2003) Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release. J Biol Chem 278:3015-22
Weinert, Craig R; Gross, Cynthia R; Marinelli, William A (2003) Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals. Am J Respir Crit Care Med 167:1304-9
Hao, Hong; Wendt, Christine H; Sandhu, Gurpreet et al. (2003) Dexamethasone stimulates transcription of the Na+-K+-ATPase beta1 gene in adult rat lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 285:L593-601

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