Abstract

The morphology component provides support for SCOR projects with research needs for immunocytochemistry, transmission or scanning electron microscopy, confocal laser scanning microscopy, cryoultramicrotomy with gold localization, TUNEL, and in situ hybridization. In addition to providing technical expertise and the facilities for carrying out these experiments, the Core C faculty will assist the SCOR project investigators in design of these procedures, interpretation of the images obtained and data analysis. Dr. Ingbar will direct the allocation of time for individual experiments by the Senior Scientist technician and will develop quantitative immunofluorescence and in situ hybridization techniques using a computer-based, image analysis system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL050152-07
Application #
6302254
Study Section
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
7
Fiscal Year
2000
Total Cost
$269,500
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Larsson, Ola; Perlman, David M; Fan, Danhua et al. (2006) Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Res 34:4375-86
Li, Shunan; Perlman, David M; Peterson, Mark S et al. (2004) Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis. J Biol Chem 279:21312-7
Lei, Jianxun; Mariash, Cary N; Ingbar, David H (2004) 3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent. J Biol Chem 279:47589-600
Tian, Bin; Han, Lei; Kleidon, Jill et al. (2003) An HSV-TK transgenic mouse model to evaluate elimination of fibroblasts for fibrosis therapy. Am J Pathol 163:789-801
Lee, So Yeong; Maniak, Peter J; Ingbar, David H et al. (2003) Adult alveolar epithelial cells express multiple subtypes of voltage-gated K+ channels that are located in apical membrane. Am J Physiol Cell Physiol 284:C1614-24
Lei, Jianxun; Nowbar, Sogol; Mariash, Cary N et al. (2003) Thyroid hormone stimulates Na-K-ATPase activity and its plasma membrane insertion in rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 285:L762-72
Li, Shunan; Takasu, Tasaburo; Perlman, David M et al. (2003) Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release. J Biol Chem 278:3015-22
Weinert, Craig R; Gross, Cynthia R; Marinelli, William A (2003) Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals. Am J Respir Crit Care Med 167:1304-9
Hao, Hong; Wendt, Christine H; Sandhu, Gurpreet et al. (2003) Dexamethasone stimulates transcription of the Na+-K+-ATPase beta1 gene in adult rat lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 285:L593-601
Hao, Hong; Rhodes, Richard; Ingbar, David H et al. (2003) Dexamethasone responsive element in the rat Na, K-ATPase beta1 gene coding region. Biochim Biophys Acta 1630:55-63

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