Abstract

The aims of this Core are to: 1. Isolate myocytes from non-failing and failing human ventricular muscle at Temple University School of Medicine and supply these myocytes to investigators involved in the SCOR on Sudden Cardiac Death at Johns Hopkins University School of Medicine. 2. Prepare tissue samples from non-failing and failing human ventricular muscle at Temple University School of Medicine for investigators involved in the SCOR on Sudden Cardiac Death at Johns Hopkins University School of Medicine. 3. Provide primary cultures of human myocytes made at Temple University School of Medicine to investigators involved in the SCOR on Sudden Cardiac Death at Johns Hopkins University School of Medicine for use in gene transfer and cell fusion experiments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL052307-08
Application #
6575132
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$209,733
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Zhu, Guangshuo; Groneberg, Dieter; Sikka, Gautam et al. (2015) Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse. Hypertension 65:385-92
Ashikaga, Hiroshi; Leclercq, Christophe; Wang, Jiangxia et al. (2010) Hemodynamic improvement in cardiac resynchronization does not require improvement in left ventricular rotation mechanics: three-dimensional tagged MRI analysis. Circ Cardiovasc Imaging 3:456-63
Sachdev, Molly; Fetics, Barry J; Lai, Shenghan et al. (2010) Failure in short-term prediction of ventricular tachycardia and ventricular fibrillation from continuous electrocardiogram in intensive care unit patients. J Electrocardiol 43:400-7
Cheng, Alan; Dalal, Darshan; Fetics, Barry J et al. (2009) Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease. J Cardiovasc Electrophysiol 20:873-9
Deschenes, Isabelle; Armoundas, Antonis A; Jones, Steven P et al. (2008) Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol 45:336-46
Armoundas, Antonis A; Rose, Jochen; Aggarwal, Rajesh et al. (2007) Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol 292:H1607-18
Tanskanen, Antti J; Alvarez, Luis H R (2007) Voltage noise influences action potential duration in cardiac myocytes. Math Biosci 208:125-46
Akar, Fadi G; Nass, Robert D; Hahn, Samuel et al. (2007) Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol 293:H1223-30
Tanskanen, Antti J; Greenstein, Joseph L; Chen, Alex et al. (2007) Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release. Biophys J 92:3379-96
Takimoto, Eiki; Belardi, Diego; Tocchetti, Carlo G et al. (2007) Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5. Circulation 115:2159-67

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