Abstract

Purpose: Core E (the Modeling Core), functions as a resource for the individual projects by providing expertise in: a) the design of mathematical models of cardiac ion channels, membrane currents, intracellular Ca handling processes, cells, and tissue; b) efficient software implementation of these models on scalar and parallel computers; and c) model-based analyses of experimental data and experimental design.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL052307-08
Application #
6575133
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$209,730
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Zhu, Guangshuo; Groneberg, Dieter; Sikka, Gautam et al. (2015) Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse. Hypertension 65:385-92
Ashikaga, Hiroshi; Leclercq, Christophe; Wang, Jiangxia et al. (2010) Hemodynamic improvement in cardiac resynchronization does not require improvement in left ventricular rotation mechanics: three-dimensional tagged MRI analysis. Circ Cardiovasc Imaging 3:456-63
Sachdev, Molly; Fetics, Barry J; Lai, Shenghan et al. (2010) Failure in short-term prediction of ventricular tachycardia and ventricular fibrillation from continuous electrocardiogram in intensive care unit patients. J Electrocardiol 43:400-7
Cheng, Alan; Dalal, Darshan; Fetics, Barry J et al. (2009) Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease. J Cardiovasc Electrophysiol 20:873-9
Deschenes, Isabelle; Armoundas, Antonis A; Jones, Steven P et al. (2008) Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol 45:336-46
Armoundas, Antonis A; Rose, Jochen; Aggarwal, Rajesh et al. (2007) Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol 292:H1607-18
Tanskanen, Antti J; Alvarez, Luis H R (2007) Voltage noise influences action potential duration in cardiac myocytes. Math Biosci 208:125-46
Akar, Fadi G; Nass, Robert D; Hahn, Samuel et al. (2007) Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol 293:H1223-30
Tanskanen, Antti J; Greenstein, Joseph L; Chen, Alex et al. (2007) Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release. Biophys J 92:3379-96
Takimoto, Eiki; Belardi, Diego; Tocchetti, Carlo G et al. (2007) Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5. Circulation 115:2159-67

Showing the most recent 10 out of 114 publications