Abstract

Core C (Antibody Production) will be responsible for the in vitro production of monoclonal antibodies for investigators in the research projects. Our experience in successfully using novel immunogens for the in vitro production of novel monoclonal antibodies to human polymorphic antigens together with our expertise in cell culture, places us in a unique position to provide the service of antibody production as a Core facility. This facility will prepare monoclonal antibodies as required by investigators in the SCOR research projects for use as diagnostic reagents, in functional assays, and for immunochemical studies. This Core facility will serve as a support service for these on-going projects and will minimize the duplication of effort within the research program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL054459-07
Application #
6564986
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
New York Blood Center
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Migliaccio, Anna Rita (2018) A vicious interplay between genetic and environmental insults in the etiology of blood cancers. Exp Hematol 59:9-13
Ciaffoni, Fiorella; Cassella, Elena; Varricchio, Lilian et al. (2015) Activation of non-canonical TGF-?1 signaling indicates an autoimmune mechanism for bone marrow fibrosis in primary myelofibrosis. Blood Cells Mol Dis 54:234-41
Hricik, Todd; Federici, Giulia; Zeuner, Ann et al. (2013) Transcriptomic and phospho-proteomic analyzes of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera. Am J Hematol 88:723-9
Poletto, Valentina; Rosti, Vittorio; Villani, Laura et al. (2012) A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation. Blood 120:3112-7
Huang, Cheng-Han; Ye, Mao (2010) The Rh protein family: gene evolution, membrane biology, and disease association. Cell Mol Life Sci 67:1203-18
Zhu, Xiang; Rivera, Alicia; Golub, Mari S et al. (2009) Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). Am J Hematol 84:492-8
Mutschler, Manuel; Magin, Angela S; Buerge, Martina et al. (2009) NF-E2 overexpression delays erythroid maturation and increases erythrocyte production. Br J Haematol 146:203-17
Ford, Louise; Lobo, Cheryl A; Rodriguez, Marilis et al. (2007) Differential antibody responses to Plasmodium falciparum invasion ligand proteins in individuals living in malaria-endemic areas in Brazil and Cameroon. Am J Trop Med Hyg 77:977-83
Peng, Jianbin; Redman, Colvin M; Wu, Xu et al. (2007) Insights into extensive deletions around the XK locus associated with McLeod phenotype and characterization of two novel cases. Gene 392:142-50
Hue-Roye, Kim; Lomas-Francis, Christine; Belaygorod, Larisa et al. (2007) Three new high-prevalence antigens in the Cromer blood group system. Transfusion 47:1621-9

Showing the most recent 10 out of 143 publications