Abstract

Our hypothesis is that molecular variants at some loci affecting blood pressure regulation predispose individuals to the development of essential hypertension. Multifactorial determination and heterogeneity suggest that several genes may account for a predominant fraction of this genetic component. In this H-SCOR, we will be examining selected genes in patients with salt/volume sensitive hypertension as outlined in Projects 1 and 2. Analysis of genetic linkage, direct search for mutations, and genotyping at select loci may help in identifying 'genetic' subgroups for physiological studies in these two projects. This core will also assist investigators in projects 3-5 in marker development or other molecular genetic approaches as the need arise.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL055000-04
Application #
6110552
Study Section
Project Start
1999-02-01
Project End
2000-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Manosroi, Worapaka; Tan, Jia Wei; Rariy, Chevon M et al. (2017) The Association of Estrogen Receptor-? Gene Variation With Salt-Sensitive Blood Pressure. J Clin Endocrinol Metab 102:4124-4135
Gupta, Tina; Connors, Molly; Tan, Jia Wei et al. (2017) Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens 31:124-131
Tan, Jia W; Gupta, Tina; Manosroi, Worapaka et al. (2017) Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight 2:
Chong, Cherish; Hamid, Anis; Yao, Tham et al. (2017) Regulation of aldosterone secretion by mineralocorticoid receptor-mediated signaling. J Endocrinol 232:525-534
Baudrand, Rene; Pojoga, Luminita H; Vaidya, Anand et al. (2015) Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects. Circulation 132:1825-33
Garza, Amanda E; Rariy, Chevon M; Sun, Bei et al. (2015) Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension 65:211-217
Brown, Jenifer M; Williams, Jonathan S; Luther, James M et al. (2014) Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension 63:273-80
Saxena, A R; Chamarthi, B; Williams, G H et al. (2014) Predictors of plasma and urinary catecholamine levels in normotensive and hypertensive men and women. J Hum Hypertens 28:292-7
Garg, Rajesh; Sun, Bei; Williams, Jonathan (2014) Effect of low salt diet on insulin resistance in salt-sensitive versus salt-resistant hypertension. Hypertension 64:1384-7
Brown, Jenifer M; Underwood, Patricia C; Ferri, Claudio et al. (2014) Aldosterone dysregulation with aging predicts renal vascular function and cardiovascular risk. Hypertension 63:1205-11

Showing the most recent 10 out of 87 publications