Abstract

narrative) The purpose of this core is to provide centralized care, breeding, genotyping and quality control of inbred rat strains, and transgenic and knockout mice used by investigators in the Center. The core will provide a mechanism for the distribution of new experimental transgenic and knockout models to Center and non-Center investigators both at the University of Iowa and outside the institution. The main responsibilities of the core will be: 1) generation of new transgenic models; 2) maintenance of genetic stocks of rats and mice; 3) genotyping transgenic and knockout mice; 4) generation of compound mutants and transgenics 5) provision of experimental and control mice to investigators; and 6) quality control.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL055006-06
Application #
6414907
Study Section
Project Start
2001-02-01
Project End
2002-01-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Mark, Allyn L (2013) Selective leptin resistance revisited. Am J Physiol Regul Integr Comp Physiol 305:R566-81
Hingtgen, Shawn D; Li, Zhenbo; Kutschke, William et al. (2010) Superoxide scavenging and Akt inhibition in myocardium ameliorate pressure overload-induced NF-?B activation and cardiac hypertrophy. Physiol Genomics 41:127-36
Lindley, Timothy E; Infanger, David W; Rishniw, Mark et al. (2009) Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction. Am J Physiol Regul Integr Comp Physiol 296:R1-8
Bianco, Robert A; Agassandian, Khristofor; Cassell, Martin D et al. (2009) Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase. Brain Res 1291:60-72
Grobe, Justin L; Xu, Di; Sigmund, Curt D (2008) An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda) 23:187-93
Shi, Peijun P; Cao, Xiao R; Sweezer, Eileen M et al. (2008) Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol 295:F462-70
Zhou, Xiyou; Weatherford, Eric T; Liu, Xuebo et al. (2008) Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus. Am J Physiol Renal Physiol 295:F642-53
Beyer, Andreas M; Baumbach, Gary L; Halabi, Carmen M et al. (2008) Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension 51:867-71
Beyer, Andreas M; de Lange, Willem J; Halabi, Carmen M et al. (2008) Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res 103:654-61
Halabi, Carmen M; Beyer, Andreas M; de Lange, Willem J et al. (2008) Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab 7:215-26

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