Abstract

: Function of the Clinical/Biostatistics Core: 1) Procurement, organization, and distribution of DNA and other samples from well characterized subjects, to service specific SCOR projects; recruitment of individuals to provide plasma and blood cells for specific SCOR projects. 2) Provision of biomathematics and biostatistics analyses in the SCOR program, including statistical analysis of genetic data, data processing and management and mathematical modeling. A major goal of the Core is to secure the DNA and blood samples subjects and analyses to define the genetic and molecular contributions to atherogenesis. This Core will fill a critical role that is required of the SCOR program in Molecular Medicine and Atherosclerosis, i.e. it will provide clinical resources (DNA, macrophages, and plasma samples) for study in the individual projects, allowing integration of basic and clinical resources. Further, the Core will facilitate collaboration among investigators, projects and cores within the Columbia University SCOR program, additional outside resources and other atherosclerosis SCOR programs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL056984-06
Application #
6577834
Study Section
Project Start
2002-04-01
Project End
2007-03-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Chen, Han; Cade, Brian E; Gleason, Kevin J et al. (2018) Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol 58:391-401
Johnson, Dayna A; Hirsch, Jana A; Moore, Kari A et al. (2018) Associations Between the Built Environment and Objective Measures of Sleep: The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 187:941-950
Johnson, Dayna A; Lane, Jacqueline; Wang, Rui et al. (2017) Greater Cognitive Deficits with Sleep-disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer Disease. The Multi-Ethnic Study of Atherosclerosis. Ann Am Thorac Soc 14:1697-1705
Cade, Brian E; Chen, Han; Stilp, Adrienne M et al. (2016) Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. Am J Respir Crit Care Med 194:886-897
Mayurasakorn, Korapat; Williams, Jill J; Ten, Vadim S et al. (2011) Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. Curr Opin Clin Nutr Metab Care 14:158-67
Devlin, Cecilia M; Leventhal, Andrew R; Kuriakose, George et al. (2008) Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler Thromb Vasc Biol 28:1723-30
Pan, Meihui; Maitin, Vatsala; Parathath, Sajesh et al. (2008) Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc Natl Acad Sci U S A 105:5862-7
Williams, Kevin Jon; Feig, Jonathan E; Fisher, Edward A (2008) Rapid regression of atherosclerosis: insights from the clinical and experimental literature. Nat Clin Pract Cardiovasc Med 5:91-102
Tabas, Ira; Williams, Kevin Jon; Boren, Jan (2007) Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 116:1832-44
Williams, Kevin Jon; Qiu, Gang; Usui, Hitomi Katoaka et al. (2007) Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol 171:1441-50

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