Abstract

The objective of the Small Animal Physiology Core is to apply state-of-the-art diagnostic modalities for characterizing murine cardiovascular physiology in vivo and in vitro to determine the effects of particular gene mutations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL061036-02
Application #
6302541
Study Section
Project Start
2000-01-25
Project End
2000-12-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2000
Total Cost
$234,991
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Pu, William T; Ishiwata, Takahiro; Juraszek, Amy L et al. (2004) GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol 275:235-44
Kasahara, Hideko; Ueyama, Tomomi; Wakimoto, Hiroko et al. (2003) Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes. J Mol Cell Cardiol 35:243-56
Ueyama, Tomomi; Kasahara, Hideko; Ishiwata, Takahiro et al. (2003) Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis. Mol Cell Biol 23:9222-32
Ishiwata, Takahiro; Nakazawa, Makoto; Pu, William T et al. (2003) Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos. Circ Res 93:857-65
Ueyama, Tomomi; Kasahara, Hideko; Ishiwata, Takahiro et al. (2003) Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart. J Biol Chem 278:28750-7
Rallis, Charalampos; Bruneau, Benoit G; Del Buono, Jo et al. (2003) Tbx5 is required for forelimb bud formation and continued outgrowth. Development 130:2741-51
Wakimoto, Hiroko; Kasahara, Hideko; Maguire, Colin T et al. (2002) Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5. J Cardiovasc Electrophysiol 13:682-8
Triedman, John K; Alexander, Mark E; Love, Barry A et al. (2002) Influence of patient factors and ablative technologies on outcomes of radiofrequency ablation of intra-atrial re-entrant tachycardia in patients with congenital heart disease. J Am Coll Cardiol 39:1827-35
Kardon, Gabrielle; Campbell, Jacquie Kloetzli; Tabin, Clifford J (2002) Local extrinsic signals determine muscle and endothelial cell fate and patterning in the vertebrate limb. Dev Cell 3:533-45
Gehrmann, J; Frantz, S; Maguire, C T et al. (2001) Electrophysiological characterization of murine myocardial ischemia and infarction. Basic Res Cardiol 96:237-50

Showing the most recent 10 out of 16 publications