Abstract

The specific aims are to provide rapid screening method for examining spatial expression patterns of differentially expressed genes to be cloned in Project 2; to permit Project 3 to localize the temporal and spatial patterns of expression of selected clones by both whole-mount and paraffin-section in situ hybridization; and to provide high quality and reproducible results for Projects 4, 5, and 6 and to prevent the unnecessary duplication of facilities and efforts among the subprojects that are involved.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL062178-02
Application #
6302557
Study Section
Project Start
2000-02-15
Project End
2000-12-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
$132,307
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Patel, Sonali S; Mahoney, Larry T; Burns, Trudy L (2012) Is a shorter atrioventricular septal length an intermediate phenotype in the spectrum of nonsyndromic atrioventricular septal defects? J Am Soc Echocardiogr 25:782-9
Bartlett, Heather L; Sutherland, Lillian; Kolker, Sandra J et al. (2007) Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis. Dev Dyn 236:2475-84
Mitchell, Tracy; Jones, Elizabeth A; Weeks, Daniel L et al. (2007) Chordin affects pronephros development in Xenopus embryos by anteriorizing presomitic mesoderm. Dev Dyn 236:251-61
Collop, Andrew H; Broomfield, Joel A S; Chandraratna, Roshantha A S et al. (2006) Retinoic acid signaling is essential for formation of the heart tube in Xenopus. Dev Biol 291:96-109
Knauert, Melissa P; Lloyd, Janice A; Rogers, Faye A et al. (2005) Distance and affinity dependence of triplex-induced recombination. Biochemistry 44:3856-64
Kalish, Jennifer M; Seidman, Michael M; Weeks, Daniel L et al. (2005) Triplex-induced recombination and repair in the pyrimidine motif. Nucleic Acids Res 33:3492-502
Zheng, Wei; Christensen, Lance P; Tomanek, Robert J (2004) Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Am J Physiol Heart Circ Physiol 287:H2739-45
Jallow, Zainab; Jacobi, Ulrike G; Weeks, Daniel L et al. (2004) Specialized and redundant roles of TBP and a vertebrate-specific TBP paralog in embryonic gene regulation in Xenopus. Proc Natl Acad Sci U S A 101:13525-30
Tomanek, Robert J; Zheng, Wei; Yue, Xinping (2004) Growth factor activation in myocardial vascularization: therapeutic implications. Mol Cell Biochem 264:3-11
Sheffield, Val C (2004) Use of isolated populations in the study of a human obesity syndrome, the Bardet-Biedl syndrome. Pediatr Res 55:908-11

Showing the most recent 10 out of 24 publications