Abstract

A1. Recovery (stem cell) project (Specific Aim 1). Neuroscience Specific Aim 1: To determine whether intracoronary autologous bone marrow angioblasts given to LVAD patients with CHF will improve their neurocognitive function and reduce the incidence of ischemic neurological events. Neuroscience Hypothesis 1: Patients with CHF on LVAD who have increased ejection fraction as a result of stem cell therapy will have greater improvement in neurocognitive function and fewer clinical neurological events than patients on LVAD without stem cell therapy with no change in ejection fraction. A2. Coagulation project (Specific Aim 3b). Neuroscience Specific Aim 2. To determine whether inhibition of the intrinsic pathway (IP) of coagulation during cardiopulmonary bypass (CPB) and during the post-operative period after LVAD implantation reduces the incidence of stroke and cognitive dysfunction. Neuroscience Hypothesis 2: Administration of IP antagonists during CPB and during the postoperative period after destination LVAD implantation in patients with CHF will reduce the occurrence of hemorrhagic and ischemic stroke both during the acute and chronic periods.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL077096-03
Application #
7422300
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2007-05-10
Project End
2010-03-31
Budget Start
2007-05-10
Budget End
2008-03-31
Support Year
3
Fiscal Year
2007
Total Cost
$136,690
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Sondermeijer, Hugo P; Witkowski, Piotr; Woodland, David et al. (2016) Optimization of alginate purification using polyvinylidene difluoride membrane filtration: Effects on immunogenicity and biocompatibility of three-dimensional alginate scaffolds. J Biomater Appl 31:510-520
Ascheim, Deborah D; Gelijns, Annetine C; Goldstein, Daniel et al. (2014) Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices. Circulation 129:2287-96
Toba, Faustino A; Visai, Livia; Trivedi, Sheetal et al. (2013) The role of ionic interactions in the adherence of the Staphylococcus epidermidis adhesin SdrF to prosthetic material. FEMS Microbiol Lett 338:24-30
Gordon, Rachel J; Weinberg, Alan D; Pagani, Francis D et al. (2013) Prospective, multicenter study of ventricular assist device infections. Circulation 127:691-702
Gordon, Rachel J; Miragaia, Maria; Weinberg, Alan D et al. (2012) Staphylococcus epidermidis colonization is highly clonal across US cardiac centers. J Infect Dis 205:1391-8
See, Fiona; Seki, Tetsunori; Psaltis, Peter J et al. (2011) Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia. J Cell Mol Med 15:2117-29
Toba, Faustino A; Akashi, Hirokazu; Arrecubieta, Carlos et al. (2011) Role of biofilm in Staphylococcus aureus and Staphylococcus epidermidis ventricular assist device driveline infections. J Thorac Cardiovasc Surg 141:1259-64
Marshall, Randolph S; Lazar, Ronald M (2011) Pumps, aqueducts, and drought management: vascular physiology in vascular cognitive impairment. Stroke 42:221-6
Festa, Joanne R; Jia, Xiaoyu; Cheung, Ken et al. (2011) Association of low ejection fraction with impaired verbal memory in older patients with heart failure. Arch Neurol 68:1021-6
Sinha, Anshu; Shahzad, Khurram; Latif, Farhana et al. (2010) Peripheral blood mononuclear cell transcriptome profiles suggest T-cell immunosuppression after uncomplicated mechanical circulatory support device surgery. Hum Immunol 71:164-9

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