Abstract

The University of Cincinnati Divisions of Cardiology and Pediatric Cardiology have a rich and stable clinical population and excellent academic environment that fosters close working relationships with each other and basic scientists to provide an outstanding opportunity for research training of physicians interested in cardiovascular diseases and an academic research career. The Division of Molecular Cardiovascular Biology at Children's Hospital and the new University of Cincinnati Heart Center provide unique training and research opportunities for fellows in both Adult and Pediatric Cardiology. The Core objective is to educate clinical research fellows and junior faculty in the specifics of what each SCCOR Project is doing, and to enhance their research skill so as to facilitate their transition to independent NIH-funded investigators. The SCCOR investigators already have a long history of success in training academic cardiovascular scientists, and the proposed Clinical Research Skills Development Core is enriched by these developments. The proposed curriculum will be important in recruiting an appropriate base of young investigators who are interested in clinical cardiovascular investigation, and will result in physician-scientists who can increase our understanding of cardiovascular disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL077101-03
Application #
7338023
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2007-01-01
Project End
2009-12-31
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
3
Fiscal Year
2007
Total Cost
$138,634
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Kim, Ka Eul; Tae, Hyun-Jin; Natalia, Petrashevskaya et al. (2016) Cardiac physiologic regulation of sub-type specific adrenergic receptors in transgenic mice overexpressing ?1- and ?2-adrenergic receptors. Clin Exp Emerg Med 3:175-180
Karch, Jason; Molkentin, Jeffery D (2015) Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circ Res 116:1800-9
Gupta, Manish K; Gulick, James; Liu, Ruijie et al. (2014) Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes. Circ Res 115:721-9
Sandri, Marco; Robbins, Jeffrey (2014) Proteotoxicity: an underappreciated pathology in cardiac disease. J Mol Cell Cardiol 71:3-10
Holmes, Michael V; Exeter, Holly J; Folkersen, Lasse et al. (2014) Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. Circ Cardiovasc Genet 7:144-50
Correll, Robert N; Eder, Petra; Burr, Adam R et al. (2014) Overexpression of the Na+/K+ ATPase ?2 but not ?1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circ Res 114:249-256
van Berlo, Jop H; Kanisicak, Onur; Maillet, Marjorie et al. (2014) c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature 509:337-41
Gupta, Manish K; Robbins, Jeffrey (2014) Post-translational control of cardiac hemodynamics through myosin binding protein C. Pflugers Arch 466:231-6
Alves, Marco L; Dias, Fernando A L; Gaffin, Robert D et al. (2014) Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins. Circ Cardiovasc Genet 7:132-143
Park, Chang Sik; Chen, Shan; Lee, Hoyong et al. (2013) Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Basic Res Cardiol 108:344

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