Abstract

The Bioinformatic Core Unit will provide services and expertise in biostatistics and informatics in support of the clinical projects in the SCCOR, Project 1-3. In addition to performing biostatistical analyses, the Core Unit with assistance with data management and curation, microarray analyses, and proteomics analyses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL081012-05
Application #
8051819
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2010-03-01
Budget End
2011-02-28
Support Year
5
Fiscal Year
2010
Total Cost
$74,984
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Ostertag, Eric M; Bdeir, Khalil; Kacir, Stephen et al. (2016) ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion 56:1775-85
Ostertag, Eric M; Kacir, Stephen; Thiboutot, Michelle et al. (2016) ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro. Transfusion 56:1763-74
Casina, Veronica C; Hu, Wenbing; Mao, Jian-Hua et al. (2015) High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome. Proc Natl Acad Sci U S A 112:9620-5
Lu, Qiongyu; Dong, Ningzheng; Wang, Qi et al. (2013) Increased levels of plasma soluble Sema4D in patients with heart failure. PLoS One 8:e64265
Wannemacher, K M; Jiang, H; Hess, P R et al. (2013) An expanded role for semaphorin 4D in platelets includes contact-dependent amplification of Clec-2 signaling. J Thromb Haemost 11:2190-3
Mou, Peipei; Zeng, Zhao; Li, Qiang et al. (2013) Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets. Blood 121:4221-30
Cines, Douglas B; McCrae, Keith R; Zheng, X Long et al. (2012) Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders. Blood 120:4134-42
Moore, David T; Nygren, Patrik; Jo, Hyunil et al. (2012) Affinity of talin-1 for the ?3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proc Natl Acad Sci U S A 109:793-8
Sun, Jessie E P; Vranic, Justin; Composto, Russell J et al. (2012) Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles. Integr Biol (Camb) 4:84-92
Litvinov, Rustem I; Mekler, Andrey; Shuman, Henry et al. (2012) Resolving two-dimensional kinetics of the integrin ?IIb?3-fibrinogen interactions using binding-unbinding correlation spectroscopy. J Biol Chem 287:35275-85

Showing the most recent 10 out of 47 publications