Abstract

The Histology Core will provide comprehensive service to the Research Projects by making available: comprehensive tissue banking;proven histology methods;reliable reagents;necessary equipment; technical assistance, and expert pathology interpretation. The Histology Core will bring not only efficiency in routine methods, but also will allow more advanced morphologic techniques to be utilized as needed. It will offer routine frozen section and paraffin-embedded histology, special histochemical stains, immunohistochemistry, immunofluorescence, photomicroscopy, image analysis, transmission electron microscopy, and laser capture microdissection. Nearly all of the necessary equipment is currently available in the Department of Pathology. These techniques will be supervised by Dr. Connolly and performed with the assistance of a Histology research assistant. This should allow investigators to assess the morphology, cellular constituents and protein expression with aortic aneurysms. The Histology Core will serve as a comprehensive Tissue Bank for this SCCOR, including database management and liquid nitrogen storage of aorta, plasma, serum, and buffy coat samples from the Projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL083800-05
Application #
8076244
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
5
Fiscal Year
2010
Total Cost
$124,598
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Pan, Cuiping; McInnes, Gregory; Deflaux, Nicole et al. (2017) Cloud-based interactive analytics for terabytes of genomic variants data. Bioinformatics 33:3709-3715
Kitagawa, Toshiro; Kosuge, Hisanori; Uchida, Masaki et al. (2017) RGD targeting of human ferritin iron oxide nanoparticles enhances in vivo MRI of vascular inflammation and angiogenesis in experimental carotid disease and abdominal aortic aneurysm. J Magn Reson Imaging 45:1144-1153
Suh, Ga-Young; Choi, Gilwoo; Herfkens, Robert J et al. (2016) Three-Dimensional Modeling Analysis of Visceral Arteries and Kidneys during Respiration. Ann Vasc Surg 34:250-60
Betz, Heather Hayes; Myers, Jonathan; Jaffe, Alyssa et al. (2015) Reproducibility of the Veterans Physical Activity Questionnaire in an elderly population. J Phys Act Health 12:376-81
Nakayama, Karina H; Joshi, Prajakta A; Lai, Edwina S et al. (2015) Bilayered vascular graft derived from human induced pluripotent stem cells with biomimetic structure and function. Regen Med 10:745-55
Spin, Joshua M; Tsao, Philip S (2014) Battle of the bulge: miR-195 versus miR-29b in aortic aneurysm. Circ Res 115:812-3
Arzani, Amirhossein; Suh, Ga-Young; Dalman, Ronald L et al. (2014) A longitudinal comparison of hemodynamics and intraluminal thrombus deposition in abdominal aortic aneurysms. Am J Physiol Heart Circ Physiol 307:H1786-95
Maegdefessel, Lars; Dalman, Ronald L; Tsao, Philip S (2014) Pathogenesis of abdominal aortic aneurysms: microRNAs, proteases, genetic associations. Annu Rev Med 65:49-62
Maegdefessel, Lars; Spin, Joshua M; Raaz, Uwe et al. (2014) miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun 5:5214
Arzani, Amirhossein; Les, Andrea S; Dalman, Ronald L et al. (2014) Effect of exercise on patient specific abdominal aortic aneurysm flow topology and mixing. Int J Numer Method Biomed Eng 30:280-95

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