Abstract

The goal of the Human Brain Bank Core is to identify, recover, assess and distribute post-mortem human brain specimens from subjects with schizophrenia and matched normal control and non-schizophrenic psychiatric comparison subjects. For all subjects, DSM-III-R and DSM-IV diagnoses are made by an independent committee of experienced clinicians (see Clinical Services Core-C) at a case conference utilizing information obtained from clinical records, toxicology and neuropathology exams, the Coroner's report, and a standardized psychological autopsy. The latter incorporates a structured interview, conducted with family members of the index case to assess diagnosis, psychopathology, medical, developmental, social and family history, medication history and handedness. All data regarding both clinical features and available brain tissue are stored in a database managed by the Statistics and Data Management Core-D, and accessible to Center investigators. The Human Brain Bank Core supports the postmortem studies proposed in Projects 1-Lewis, 2-Levitt and 8-Sweeney in the CNMD, as ell as a number of other studies funded through mechanisms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH045156-12
Application #
6456272
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
2001
Total Cost
$228,564
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Cai, HuaLin; Zhou, Xiang; Dougherty, George G et al. (2018) Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinology 90:43-51
Stevenson, J M; Reilly, J L; Harris, M S H et al. (2016) Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. Transl Psychiatry 6:e739
Lizano, Paulo L; Keshavan, Matcheri S; Tandon, Neeraj et al. (2016) Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study. Schizophr Res 170:115-22
Bishop, Jeffrey R; Reilly, James L; Harris, Margret S H et al. (2015) Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia. Psychopharmacology (Berl) 232:145-54
Horton, Leslie E; Tarbox, Sarah I; Olino, Thomas M et al. (2015) Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: A first-episode study. Psychiatry Res 227:339-46
Hall, Nathan; Colby, Carol (2014) S-cone visual stimuli activate superior colliculus neurons in old world monkeys: implications for understanding blindsight. J Cogn Neurosci 26:1234-56
Subramanian, Janani; Colby, Carol L (2014) Shape selectivity and remapping in dorsal stream visual area LIP. J Neurophysiol 111:613-27
Berdyyeva, Tamara K; Olson, Carl R (2014) Intracortical microstimulation of supplementary eye field impairs ability of monkeys to make serially ordered saccades. J Neurophysiol 111:1529-40
Lencer, Rebekka; Bishop, Jeffrey R; Harris, Margret S H et al. (2014) Association of variants in DRD2 and GRM3 with motor and cognitive function in first-episode psychosis. Eur Arch Psychiatry Clin Neurosci 264:345-55
McCracken, Clinton B; Grace, Anthony A (2013) Persistent cocaine-induced reversal learning deficits are associated with altered limbic cortico-striatal local field potential synchronization. J Neurosci 33:17469-82

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