Abstract

The HNRC Outcomes Core will apply a variety of current measures of patient functioning. The Core uses the conceptual framework suggested by the World Health Organization (WHO), which classifies outcomes into impairment, disability, and handicap. Measures of impairment will be gained through collaboration with other HNRC cores. Disability will be assessed using two health-related quality of life measures: The Quality of Well-being scale (QWB) and the medical Outcomes Study HIV Specific (MOS-HIV). Handicap will be evaluated using measures of work function and validated measures of social adjustment. In addition to service functions, the Outcome Core will produce original research documenting the effectors of HIV infection in the central nervous system upon measures of disability and handicap. Further, original research on human information processing relevant to the evaluation of health status will be produced. These studies will determine whether weighting systems commonly used in outcomes measures are appropriate for HIV infected patients and whether infection in the central nervous system affects cognitive algebra's used to combine information. The Outcomes Core will actively collaborate with all other Cores and projects within the HNRC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH045294-07
Application #
3737756
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Joseph, Jeymohan; Cinque, Paola; Colosi, Deborah et al. (2016) Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA. J Virus Erad 2:243-250
Bharti, Ajay R; Woods, Steven Paul; Ellis, Ronald J et al. (2016) Fibroblast growth factors 1 and 2 in cerebrospinal fluid are associated with HIV disease, methamphetamine use, and neurocognitive functioning. HIV AIDS (Auckl) 8:93-9
Weinrich, James D; Klein, Fritz; McCutchan, J Allen et al. (2014) Cluster Analysis of the Klein Sexual Orientation Grid in Clinical and Nonclinical Samples: When Bisexuality Is Not Bisexuality. J Bisex 14:349-372
Wrasidlo, Wolf; Crews, Leslie A; Tsigelny, Igor F et al. (2014) Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol 171:5757-73
Klein, Fritz; Weinrich, James D (2014) Homogeneous Gynephiles and Heterogeneous Androphiles: A Factor Analysis of Differences and Similarities in Attractions to the Sexes as a Function of Sexual Orientation. J Bisex 14:468-501
Fields, Jerel; Dumaop, Wilmar; Rockenstein, Edward et al. (2013) Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol 19:89-101
Desplats, Paula; Dumaop, Wilmar; Smith, David et al. (2013) Molecular and pathologic insights from latent HIV-1 infection in the human brain. Neurology 80:1415-23
Gelman, Benjamin B; Lisinicchia, Joshua G; Morgello, Susan et al. (2013) Neurovirological correlation with HIV-associated neurocognitive disorders and encephalitis in a HAART-era cohort. J Acquir Immune Defic Syndr 62:487-95
Soontornniyomkij, Virawudh; Everall, Ian P; Moore, David J et al. (2012) Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. J Neurovirol 18:313-22
Soontornniyomkij, Virawudh; Moore, David J; Gouaux, Ben et al. (2012) Cerebral ?-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ?4 carriers. AIDS 26:2327-35

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