Normal human subjects differ greatly in their reactions to emotional stimuli and situations. Emotional responses can be classified fundamentally as appetitive or aversive, and temperamental variations in motivational systems are believed to be an important mediator of individual differences in response to emotional stimuli. The proposed research applies new methodologies for measuring appetitive and aversive emotion (including startle modification) to the study of normal human temperament and its deviant extremes. Psychopathic personality, which has a constitutional basis and which is marked by striking affective deficits, presents a potent model for the study of emotion and temperament. A series of six studies is proposed to explore psychophysiological markers of temperament in competing appetitive and aversive stimulus contexts, to investigate the temperamental basis of psychopathy and antisocial personality, and to investigate links between emotional deviance in psychopaths and normal variations in temperament. Extending previous work, experiments are proposed to examine affective responding during anticipation of pleasant, neutral, and affectively ambiguous pictorial stimuli, and to examine transfer of affect in the context of more realistic, evocative film presentations. The promise of this research lies in the development of physiologically-based markers of affective individual differences and in an improved understanding of the relationship between psychopathy and normal temperament.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH052384-04
Application #
6243297
Study Section
Project Start
1997-09-30
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Florida
Department
Type
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Gollan, Jackie K; Norris, Catherine J; Hoxha, Denada et al. (2014) Spatial affect learning restricted in major depression relative to anxiety disorders and healthy controls. Cogn Emot 28:36-45
Drislane, L E; Vaidyanathan, U; Patrick, C J (2013) Reduced cortical call to arms differentiates psychopathy from antisocial personality disorder. Psychol Med 43:825-35
Verona, Edelyn; Bresin, Konrad; Patrick, Christopher J (2013) Revisiting psychopathy in women: Cleckley/Hare conceptions and affective response. J Abnorm Psychol 122:1088-93
McTeague, Lisa M; Lang, Peter J; Wangelin, Bethany C et al. (2012) Defensive mobilization in specific phobia: fear specificity, negative affectivity, and diagnostic prominence. Biol Psychiatry 72:8-18
Bernat, Edward M; Nelson, Lindsay D; Steele, Vaughn R et al. (2011) Externalizing psychopathology and gain-loss feedback in a simulated gambling task: dissociable components of brain response revealed by time-frequency analysis. J Abnorm Psychol 120:352-64
Ferrari, Vera; Bradley, Margaret M; Codispoti, Maurizio et al. (2011) Repetitive exposure: brain and reflex measures of emotion and attention. Psychophysiology 48:515-22
Vaidyanathan, Uma; Hall, Jason R; Patrick, Christopher J et al. (2011) Clarifying the role of defensive reactivity deficits in psychopathy and antisocial personality using startle reflex methodology. J Abnorm Psychol 120:253-8
Jovanovic, Tanja; Norrholm, Seth D; Blanding, Nineequa Q et al. (2010) Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD. Psychoneuroendocrinology 35:846-57
Norris, Catherine J; Gollan, Jackie; Berntson, Gary G et al. (2010) The current status of research on the structure of evaluative space. Biol Psychol 84:422-36
Hicks, Brian M; Vaidyanathan, Uma; Patrick, Christopher J (2010) Validating female psychopathy subtypes: differences in personality, antisocial and violent behavior, substance abuse, trauma, and mental health. Personal Disord 1:38-57

Showing the most recent 10 out of 114 publications