The aim of this project is to investigate the brain s response to affective stimuli: 1) to assess the validity of the animal model of motivation defined by Davis, LeDoux, Morgenson, and others, as a design for human brain function in emotion; 2) to evaluate current views of differential cortical activation in human emotion, and examine their relationship to the motivational view; 3) to determine the brain s response to stimuli that vary along the motivational parameters of pleasure and arousal, and 4) to assess differences and covariations between spatially sensitive (fMRI) and temporally sensitive (EEG measures of motivational activation in the brain. An integrative analytic effort will aim to capitalize on each measures unique advantages. In this procedure, emotionally evocative stimuli are presented in different media (i.e., pictures, sounds, or texts) that share the same affective content, in order to define consistently active neuroanatomical regions that reflect affective processes, as opposed to sites unique to modality of input or language mediation. Affect content is operationally defined both by scaled evaluative judgements of pleasure and arousal and by psychophysiological response.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH052384-09
Application #
6664621
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
9
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Florida
Department
Type
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Gollan, Jackie K; Norris, Catherine J; Hoxha, Denada et al. (2014) Spatial affect learning restricted in major depression relative to anxiety disorders and healthy controls. Cogn Emot 28:36-45
Drislane, L E; Vaidyanathan, U; Patrick, C J (2013) Reduced cortical call to arms differentiates psychopathy from antisocial personality disorder. Psychol Med 43:825-35
Verona, Edelyn; Bresin, Konrad; Patrick, Christopher J (2013) Revisiting psychopathy in women: Cleckley/Hare conceptions and affective response. J Abnorm Psychol 122:1088-93
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Ferrari, Vera; Bradley, Margaret M; Codispoti, Maurizio et al. (2011) Repetitive exposure: brain and reflex measures of emotion and attention. Psychophysiology 48:515-22
Vaidyanathan, Uma; Hall, Jason R; Patrick, Christopher J et al. (2011) Clarifying the role of defensive reactivity deficits in psychopathy and antisocial personality using startle reflex methodology. J Abnorm Psychol 120:253-8
Jovanovic, Tanja; Norrholm, Seth D; Blanding, Nineequa Q et al. (2010) Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD. Psychoneuroendocrinology 35:846-57
Norris, Catherine J; Gollan, Jackie; Berntson, Gary G et al. (2010) The current status of research on the structure of evaluative space. Biol Psychol 84:422-36
Hicks, Brian M; Vaidyanathan, Uma; Patrick, Christopher J (2010) Validating female psychopathy subtypes: differences in personality, antisocial and violent behavior, substance abuse, trauma, and mental health. Personal Disord 1:38-57

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