Abstract

The Core will identify and recruit patients and normal control subjects suitable for the human studies. It will characterize the research subjects with standardized diagnostic instruments, symptom rating scales, and neuropsychological tests. It will provide saliva samples for cortisol measures. It will perform structural and functional brain image acquisition with magnetic resonance imaging and positron emission tomography. It will perform functional image processing and statistical analyses with dedicated computer hardware and specialized software. It will provide treatment to patient subjects according to standardized protocols. The Core will also provide multidisciplinary expertise in neuropsychiatry, human behavioral neuroanatomy, and functional neuroimaging methodology and study design. This core will serve Project 1 (functional imaging of normal humans), Project 2 (functional imaging of patients with pathological fear), and Project 4 (structural imaging of hippocampus in normal humans and patients).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH058911-04
Application #
6657608
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

McEwen, Bruce S (2017) Neurobiological and Systemic Effects of Chronic Stress. Chronic Stress (Thousand Oaks) 1:
McEwen, Bruce S; Gray, Jason; Nasca, Carla (2015) Recognizing Resilience: Learning from the Effects of Stress on the Brain. Neurobiol Stress 1:1-11
Ostroff, Linnaea E; Manzur, Mustfa K; Cain, Christopher K et al. (2014) Synapses lacking astrocyte appear in the amygdala during consolidation of Pavlovian threat conditioning. J Comp Neurol 522:2152-63
Burghardt, Nesha S; Sigurdsson, Torfi; Gorman, Jack M et al. (2013) Chronic antidepressant treatment impairs the acquisition of fear extinction. Biol Psychiatry 73:1078-86
Diaz-Mataix, Lorenzo; Ruiz Martinez, Raquel Chacon; Schafe, Glenn E et al. (2013) Detection of a temporal error triggers reconsolidation of amygdala-dependent memories. Curr Biol 23:467-72
Isogawa, Koichi; Bush, David E A; LeDoux, Joseph E (2013) Contrasting effects of pretraining, posttraining, and pretesting infusions of corticotropin-releasing factor into the lateral amygdala: attenuation of fear memory formation but facilitation of its expression. Biol Psychiatry 73:353-9
Kamphausen, Susanne; Schröder, Patricia; Maier, Simon et al. (2013) Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. World J Biol Psychiatry 14:307-18, S1-4
Bloss, Erik B; Puri, Rishi; Yuk, Frank et al. (2013) Morphological and molecular changes in aging rat prelimbic prefrontal cortical synapses. Neurobiol Aging 34:200-10
Debiec, Jacek; Diaz-Mataix, Lorenzo; Bush, David E A et al. (2013) The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association. Learn Mem 20:695-9
Hunter, Richard G; Murakami, Gen; Dewell, Scott et al. (2012) Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response. Proc Natl Acad Sci U S A 109:17657-62

Showing the most recent 10 out of 158 publications