The primary objective of the Neuroimaging Core is to serve the clinical Projects 1 and 2 which utilize MRIimage acquisition and processing technology.. The core provides quantitative measurements of structuralMRI (sMRI), MR Diffusion Tensor Imaging (DTI), and functional MRI (fMRI), and prepares the quantitativeresults for analysis by the Biostatistics Core. The core utilizes images from state-of-the-art high-fieldscanner MRI technology, and ensures optimized pulse sequences for imaging of neonates and youngchildren (3T Siemens Allegra head-only) and adolescents. (3T GE). The core will provide well establishedand validated image analysis methods and will also introduce novel methods driven by the needs of theseprojects. Given the specialized expertise of our multi-disciplinary group and the close collaboration of ourresearchers with other large national programs which are of crucial importance for this project(Bioinformatics Research Network BIRN, National Alliance of Medical Image Computing NA-MIC, NLM-sponsored Insight Toolkit ITK developments), we will not only provide service to projects with well-established methodology, but will continue to develop advanced, novel image processing tools necessary toadvance the field. This Core enables Center investigators to utilize optimal methods for image data analysisusing the full range of MRI capabilities, and thus enables imaging research which addresses highly relevantpre-clinical research of brain development and alterations thereof in subjects at risk for schizophrenia.Focusing on the earliest age range possible for neuroimaging (neonates to 6 year old subjects) with studyingbrain growth in a longitudinal study (which provides a perspective that is unattainable with cross-sectionalsamples), and secondly focusing on altered brain structure and function in children and adolescence atgenetric risk for schizophrenia, coupled with applying novel innovative image analysis tools, are all inaccordance with the mission of NIH funded projects to get better insight into cause and origin of disease.
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