This is a revised application to establish a Translational Research Center in the Behavioral Sciences, consistent with the NIMH program announcement PAR-01-027. The proposed """"""""Center for Neurocognition and Emotion in Schizophrenia"""""""" has been developed through the formation of newly formed research teams that integrate basic behavioral researchers and clinical researchers to facilitate meaningful and novel collaborations. We will focus on two basic behavioral domains that are fundamental to schizophrenia: neurocognition and emotion. The three primary overarching aims of the proposed Center are: 1) to translate major advances in basic behavioral research on cognitive and emotional processes into new clinical research; 2) to advance our understanding of the fundamental role that core neurocognitive and affective abnormalities play in functional outcome for individuals with schizophrenia; and 3) to examine different phases of illness as well as the shortterm developmental course of schizophrenia as means of shedding much more light on the roles of the core neurocognitive and emotional abnormalities in illness onset, progression, or recovery. To do this, we have formed teams of clinical investigators and basic behavioral investigators for six research projects. The projects range from those addressing relatively basic neurocognitive processes (""""""""Development of Automaticity"""""""", """"""""Encoding and Retrieval Processes in Long-Term Memory"""""""", """"""""Attention and Dual-Task Interference"""""""") to one addressing primarily emotional processes (""""""""Stress and Emotional Reactivity""""""""), with two projects at the interface between neurocognitive and emotional processes (""""""""Social Cognition: Interpersonal and Emotional Processes"""""""", """"""""Associative Learning and Emotion Regulation""""""""). The formation of new teams of basic and clinical investigators will permit us to study processes relevant to schizophrenia that have not been studiedthrough these novel paradigms. Seven cores will directly serve the needs of the research projects and the translational behavioral science mission of the Center: 1) the Administration and Training Core, 2) three service cores (a Data and Methodology Core, a Functional Outcomes Core, and a Diagnosis and Symptom Assessment Core), and 3) three clinical cores (Prevention Research Program, Aftercare Research Program, and Chronic Schizophrenia Recruitment and Assessment Core).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH066286-03
Application #
6917077
Study Section
Special Emphasis Panel (ZMH1-NRB-Q (06))
Program Officer
Heinssen, Robert K
Project Start
2003-09-19
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
3
Fiscal Year
2005
Total Cost
$1,789,731
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lee, Junghee; Nuechterlein, Keith H; Knowlton, Barbara J et al. (2018) Episodic Memory for Dynamic Social Interaction Across Phase of Illness in Schizophrenia. Schizophr Bull 44:620-630
Velthorst, Eva; Meyer, Eric C; Giuliano, Anthony J et al. (2018) Neurocognitive profiles in the prodrome to psychosis in NAPLS-1. Schizophr Res :
Chen, Qiaolin; Sugar, Catherine A; Weiss, Robert E (2018) A Bayesian confirmatory factor model for multivariate observations in the form of two-way tables of data. Stat Med 37:1696-1710
Hamilton, Holly K; Williams, Terrance J; Ventura, Joseph et al. (2018) Clinical and Cognitive Significance of Auditory Sensory Processing Deficits in Schizophrenia. Am J Psychiatry 175:275-283
Clayson, Peter E; Kern, Robert S; Nuechterlein, Keith H et al. (2018) Social vs. non-social measures of learning potential for predicting community functioning across phase of illness in schizophrenia. Schizophr Res :
Hampton, Joya N; Trotman, Hanan D; Addington, Jean et al. (2018) The relation of atypical antipsychotic use and stress with weight in individuals at clinical high risk for psychosis. Stress Health 34:591-600
Kline, Emily R; Seidman, Larry J; Cornblatt, Barbara A et al. (2018) Depression and clinical high-risk states: Baseline presentation of depressed vs. non-depressed participants in the NAPLS-2 cohort. Schizophr Res 192:357-363
Fernandez, Vindia G; Asarnow, Robert; Narr, Katherine L et al. (2018) Temporal lobe thickness and verbal memory in first-degree relatives of individuals with schizophrenia. Schizophr Res 199:221-225
Woodberry, Kristen A; Seidman, Larry J; Bryant, Caitlin et al. (2018) Treatment Precedes Positive Symptoms in North American Adolescent and Young Adult Clinical High Risk Cohort. J Clin Child Adolesc Psychol 47:69-78
Grazioplene, Rachael G; Bearden, Carrie E; Subotnik, Kenneth L et al. (2018) Connectivity-enhanced diffusion analysis reveals white matter density disruptions in first episode and chronic schizophrenia. Neuroimage Clin 18:608-616

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