The computer core will enhance the interaction of the four individual projects in the CCNR by providinggeneral resources for computer programming, systems management and data storage. The multi-unitrecording studies proposed in and the fMRI studies all result invery large data sets, and the computational modeling produces similarly large simulation outputfiles. The ability to safely and reliably store, backup, access and transfer data is an integral component of allof the projects which will greatly facilitate the analysis of data within the experimental projects, and thecomparison of data between experiments and with the experimental predictions from computationalsimulations. Currently, the experimental projects are impeded by limitations on data storage requiring theremoval of files produced by intermediate stages of analysis, and the comparison of data sets is impeded bythe separation of networks and data formats between laboratories. A full time systems operator will greatlyfacilitate the maintenance of adequate storage and the network mechanisms for interaction betweenprojects. In addition, there is a strong need for a full-time programmer to provide software development forenhancing research interactions including: a.) Translation of experimental data and simulation output to acommon data format, b.) Development of common data analysis software to be used by all projectsperforming similar analysis, such as analysis of spike timing relative to theta rhythm oscillations, c.)Development of unified software for presentation of data and model output in the same format, d.)Development and maintenance of common scripts in MATLAB and CATACOMB for simulation ofhippocampus, entorhinal cortex and prefrontal cortex, and e.) Assistance with programming of data collectionand behavioral tasks for individual projects. The development of unified data formats, analysis programs andsimulations scripts will provide fundamental resources for the outreach and data sharing of this center, madeavailable on the center web site. Thus, the computer core will enhance the synergistic interaction of the fourprojects within the center, and the interaction with the scientific community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH071702-01A2
Application #
7163265
Study Section
Special Emphasis Panel (ZMH1-ERB-A (03))
Project Start
2006-07-01
Project End
2011-06-30
Budget Start
2006-07-01
Budget End
2007-08-31
Support Year
1
Fiscal Year
2006
Total Cost
$212,354
Indirect Cost
Name
Boston University
Department
Type
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215
Kraus, Benjamin J; Brandon, Mark P; Robinson 2nd, Robert J et al. (2015) During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run. Neuron 88:578-89
Brown, Thackery I; Hasselmo, Michael E; Stern, Chantal E (2014) A high-resolution study of hippocampal and medial temporal lobe correlates of spatial context and prospective overlapping route memory. Hippocampus 24:819-39
Prerau, Michael J; Lipton, Paul A; Eichenbaum, Howard B et al. (2014) Characterizing context-dependent differential firing activity in the hippocampus and entorhinal cortex. Hippocampus 24:476-92
Brown, Thackery I; Whiteman, Andrew S; Aselcioglu, Irem et al. (2014) Structural differences in hippocampal and prefrontal gray matter volume support flexible context-dependent navigation ability. J Neurosci 34:2314-20
Brown, Thackery I; Stern, Chantal E (2014) Contributions of medial temporal lobe and striatal memory systems to learning and retrieving overlapping spatial memories. Cereb Cortex 24:1906-22
Kraus, Benjamin J; Robinson 2nd, Robert J; White, John A et al. (2013) Hippocampal ""time cells"": time versus path integration. Neuron 78:1090-101
Ross, Robert S; LoPresti, Matthew L; Schon, Karin et al. (2013) Role of the hippocampus and orbitofrontal cortex during the disambiguation of social cues in working memory. Cogn Affect Behav Neurosci 13:900-15
Erdem, U?ur M; Hasselmo, Michael (2012) A goal-directed spatial navigation model using forward trajectory planning based on grid cells. Eur J Neurosci 35:916-31
Brown, Thackery I; Ross, Robert S; Tobyne, Sean M et al. (2012) Cooperative interactions between hippocampal and striatal systems support flexible navigation. Neuroimage 60:1316-30
Lepage, Kyle Q; Macdonald, Christopher J; Eichenbaum, Howard et al. (2012) The statistical analysis of partially confounded covariates important to neural spiking. J Neurosci Methods 205:295-304

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